| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-36126 |
Borussertib
|
1800070-77-2 |
Borussertib is a potent, first-in-class, covalent-allosteric AKT inhibitor with IC50 of 0.8 nM and Ki of 2.2 nM for WT Akt. |
| PC-61416 |
LY2780301
|
1226801-23-5 |
LY2780301 is a potent, highly selective, ATP-competitive dual inhibitor of p70S6K and Akt under development for the treatment of solid tumours and non-Hodgkin's lymphoma. |
| PC-42032 |
BAY-1125976
|
1402608-02-9 |
BAY-1125976 is a potent and highly selective, allosteric AKT1/2 inhibitor with IC50 of 5.2/18 nM at 10 uM ATP. |
| PC-49529 |
AZD5363
|
1143532-39-1 |
Capivasertib (AZD5363) is a potent, selective and orally bioavailable inhibitor of pan-Akt kinases with IC50 of <10 nM. |
| PC-49355 |
ALM301
|
1313438-84-4 |
ALM301 is a potent, selective and allosteric inhibitor of AKT1 and AKT2 with IC50 of 125 nM and 95 nM respectively. |
| PC-49017 |
Ipatasertib
|
1001264-89-6 |
Ipatasertib (GDC-0068) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively. |
| PC-38489 |
NSC 177223
|
36707-00-3 |
NSC 177227 (API-1) is a selective small molecule Akt/protein kinase B inhibitor, efficiently reduces the S473 phosphorylation levels of Akt with IC50 of 0.8 uM, binds to Akt PH domain and inhibits Akt membrane translocation. |
