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Cat. No. Product Name Information
PC-49529

AZD5363

pan-AKT inhibitor

Capivasertib (AZD5363) is a potent, selective and orally bioavailable inhibitor of pan-Akt kinases with IC50 of <10 nM.
PC-49355

ALM301

AKT inhibitor

ALM301 is a potent, selective and allosteric inhibitor of AKT1 and AKT2 with IC50 of 125 nM and 95 nM respectively.
PC-49017

Ipatasertib

Akt inhibitor

Ipatasertib (GDC-0068) is a potent, selective, orally bioavailable pan-Akt inhibitor with IC50 values of 5 nM, 18 nM, and 8 nM for Akt1, Akt2, and Akt3, respectively.
PC-38489

NSC 177223

Akt inhibitor

NSC 177227 (API-1) is a selective small molecule Akt/protein kinase B inhibitor, efficiently reduces the S473 phosphorylation levels of Akt with IC50 of 0.8 uM, binds to Akt PH domain and inhibits Akt membrane translocation.
PC-38377

Vevorisertib trihydrochloride

pan-AKT inhibitor

Vevorisertib trihydrochloride (MK-4440, ARQ 751) is a novel potent, selective, allosteric pan-AKT inhibitor with IC50 of 0.55 nM, 0.81 nM and 1.31 nM for AKT1, 2 and 3, respectively.
PC-38375

Vevorisertib

pan-AKT inhibitor

Vevorisertib (MK-4440, ARQ 751) is a novel potent, selective, allosteric pan-AKT inhibitor with IC50 of 0.55 nM, 0.81 nM and 1.31 nM for AKT1, 2 and 3, respectively.
PC-38198

TAS0612

YBX1 inhibitor

TAS0612 (TAS-0612) is an orally bioavailable multikinase inhibitor of AKT, p70S6K, and p90RSK, inhibits Y-box-binding protein (YBX1) phosphorylation.
PC-36126

Borussertib

Akt inhibitor

Borussertib is a potent, first-in-class, covalent-allosteric AKT inhibitor with IC50 of 0.8 nM and Ki of 2.2 nM for WT Akt.
PC-35326

Ch-319

Akt inhibitor

Ch-319 (Ch319) is a triphenyltin (IV) carboxylate derivative that modulates AKT/FOXO3a signaling and inhibits progression of prostate cancer.
PC-63553

TAS-117 hydrochloride

Akt inhibitor

TAS-117 (Pifusertib) hydrochloride is a highly selective, oral, allosteric pan-AKT inhibitor with IC50 of 4.8/1.6/44 nM for Akt1/Akt2/Akt3 respectively.
PC-43440

CCT128930

Akt inhibitor

CCT128930 is a potent, selective, ATP-competitive AKT inhibitor with IC50 of 6 nM (AKT2), 28-fold selectivity over the closely related PKA.
PC-43434

A-674563 hydrochloride

Akt inhibitor

A-674563 hydrochloride is a potent, selective and orally available AKT inhibitor with Ki of 11 nM (Akt1).

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