You are here:Home-Chemical Inhibitors & Agonists-PI3K/Akt/mTOR Pathway-PI3K

Request The Product List ofPI3K PI3K

Cat. No. Product Name Information
PC-23166

Linperlisib

PI3Kδ inhibitor

Linperlisib (YY-20394) is a potent, selective and orally active PI3Kδ inhibitor (IC50=4.6 nM), inhibitr PI3Kδ expressing human tumor cells growth both in vitro and in vivo.
PC-22458

AS-252424

PI3Kγ inhibitor

AS-252424 is a potent, and selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ) with IC50 of 30 nM, 30-fold selective over PI3Kα, also is a potent ferroptosis inhibitor targeting ACSL4.
PC-22175

KTC1101

pan-PI3K inhibitor

KTC1101 is a potent, selective pan-PI3K inhibitor with IC50 of 3.72 nM for PI3Kα, 36.29 nM for PI3Kβ, 1.22 nM for PI3Kδ, and 17.09 nM for PI3Kγ.
PC-21298

RLY-2608

PI3Kα H1047R inhibitor

RLY-2608 (RLY2608) is a first-in-class, allosteric, mutant-selective inhibitor of PI3Kα with IC50 of 4 nM (PI3Kα H1047R), 12-fold selective over PI3Kα WT.
PC-21139

STX-478

PI3Kα H1047R inhibitor

STX-478 (STX478) is a potent, mutant-selective, allosteric PI3Kα inhibitor with IC50 of 9.4 nM (PI3Kα H1047R), 14-fold selectivity over WT PI3Kα (IC50=131 nM).
PC-20848

UCL-TRO-1938

PI3Kα activator

UCL-TRO-1938 (Compound 1938) is a selective, allosteric activator of PI3Kα with EC50 of 60 uM (based on in vitro lipid kinase activity), directly activates PI3Kα signalling in cells.
PC-20591

IOA-244

PI3Kδ inhibitor

IOA-244 (Roginolisib, MSC2360844) is a potent, selective and non-ATP-competitive PI3Kδ inhibitor with IC50 of 19 nM, selective over PI3Kβ (0.43 uM), Vps34 (9 uM) and PI3Kα (10.1 uM).
PC-20590

Alpelisib

PI3Kα inhibitor

Alpelisib (NVP-BYL719, BYL719) is ia potent, selective, and orally active PI3Kα inhibitor with IC50 of 5 nM, >50-fold selectivity over p110γ/p110δ/p110β.
PC-20534

Copanlisib

PI3K inhibitor

Copanlisib (BAY 80-6946) is a potent, highly selective pan-class I PI3K inhibitor with IC50 of 0.5, 3.7, 6.4, and 0.7 nM for PI3Kα, β, γ, and δ isoforms, respectively.
PC-20468

PI3Kβ inhibitor (P)-14

PI3Kβ inhibitor

PI3Kβ inhibitor (P)-14 is a potent, highly selective and orally bioavailable PI3Kβ inhibitor with IC50 of 2 nM.
PC-20453

TGX286

p110β inhibitor

TGX286 is a potent, selective p110β inhibitor with IC50 of 7, 17 and 13 nM for p110β WT, p110β D862Q, and p110β E858H, respectively, >100-fold selectivity over p110α.
PC-20375

VPS34 inhibitor 5

Vps34 inhibitor

VPS34 inhibitor 5 is a potent, selective, and orally bioavailable VPS34 inhibitor with IC50 of 83 nM, >95-fold selectivity over other PIK family kinases.

Request The Product List

* Indicates a Required FieldYour information is safe with us.

  • *Product List:
  • *Applicant name:
  • *Email address:
  • *Organization name:
  • *Country:
  • Additional Information:

Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

Contact Us sales@probechem.com