| Cat. No. |
Product Name |
Information |
| PC-28807 |
AZD3458
PI3Kγ inhibitor
|
AZD3458 (AZD-3458) is a potent and remarkably selective PI3Kγ inhibitor with pIC50 of 9.1, displays >100-fold selectivity over PI3Kα/β/δ. |
| PC-28717 |
Macamide B
Autophagy modulator
|
Macamide B is an effective active ingredient of maca, exerts a neuroprotective effect on neonatal hypoxic-ischemic brain damage (HIBD), enhances autophagy through the PI3K/AKT signaling pathway. |
| PC-28715 |
Columbianadin
PI3K/Akt inhibitor
|
Columbianadin is a coumarin from heracleum brunonis with anti-inflammatory, analgesic, thrombogenesis-inhibiting and anti-tumor effects. inhibits the PI3K/Akt signaling pathway in GBM cells. |
| PC-28709 |
Pilaralisib
PI3K inhibitor
|
Pilaralisib (XL147, SAR245408) is a potent and highly selective, orally active class I PI3Ks inhibitor with IC50s of 39 nM, 383 nM, 23 nM and 36 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively. |
| PC-28524 |
Zinilisib
PI3Kα H1047R inhibitor
|
Zinilisib (OKI-219) is a potent, highly mutant-selective, brain penetrant and orally bioavailable inhibitor of PI3kα H1047 mutant, 100-fold selectivity for PI3KαH1047R over PI3KαWT. |
| PC-28413 |
VG220
p85α-cSH2-PI(3,5)P2 inhibitor, PI3K activator
|
VG220 is a selective small-molecule inhibitor of p85α-cSH2-PI(3,5)P2 interaction with IC50 of 4.2 uM, promotes prolonged activation of PI3K. |
| PC-28409 |
SBS-873
p110α/GDH1 inhibitor
|
SBS-873 is a first-in-class p110α/GDH1 (Glutamate dehydrogenase 1) dual inhibitor, downregulates the p110α subunit, and suppresses PI3K/Akt/mTOR pathway, triggers ferroptotic cell death through glutathione depletion, GPX4 impairment, and lipid peroxidation. |
| PC-27968 |
P110δ-IN-1
p110δ inhibitor
|
p110δ-IN-1 is a potent, highly selective p110δ PI3K inhibitor with IC50 of 8.4 nM. |
| PC-27528 |
Polyphyllin I
PI3K inhibitor
|
Polyphyllin I is a steroidal saponin isolated from Paris polyphylla with broad and strong anticancer effect, induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal, inhibits PI3K kinase with IC50 of 0.84 uM. |
| PC-26519 |
BLU3797
PIK3C2B inhibitor
|
BLU3797 is a highly potent, selective, orally bioavailable PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase) inhibitor with IC50 of 28 nM (1 mM ATP), while sparing other PI3K family members. |
| PC-25861 |
740Y-P
PI3K activator
|
740Y-P (PDGFR 740Y-P, 740 Y-P, 740YP) is a potent and cell-permeable PI3K activator/agonist, binds to SH2 domain of p85 regulatory subunit of PI3-kinase, induces iNOS expression and SGHPL-4 cell motility. |
| PC-24644 |
BBO-10203
RAS-PI3Kα inhibitor
|
BBO-10203 is a first-in-class inhibitor of the RAS-PI3Kα interaction, binds specifically and cocalently to the RBD of PI3Kα (IC50=3 nM), disrupts PI3Kα interaction with K-,H-, and N-RAS with low single digit nanomolar potency (5 nM). |
