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Cat. No. Product Name Information
PC-21990

SIRT6 inhibitor 11e

SIRT6 inhibitor

SIRT6 inhibitor 11e (Compound 11e) is a potent, selective and allosteric SIRT6 inhibitor with IC50 of 0.98 uM, directly binds to SIRT6 with Kd of 9.46 uM, inhibits pancreatic cancer metastasis in vitro and vivo.
PC-20271

40569Z

SIRT7 inhibitor

40569Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.
PC-20270

2800Z

SIRT7 inhibitor

2800Z is a specific SIRT7 inhibitor, significantly inhibits SIRT7 deacetylation activity without effects on SIRT1 and SIRT6 activities, induces apoptosis and increases chemosensitivity to sorafenib in human liver cancer.
PC-20269

MDL-811

SIRT6 activator

MDL-811 (MDL811) is a potent, selective and allosteric SIRT6 activator with EC50 of 5.7 uM (activated SIRT6 deacetylation), two-fold greater activity than MDL-800 (EC50=12.3 uM, Cat# 35760).
PC-49474

SCIC2.1

SIRT1 activator

SCIC2.1 is a potent small molecule SIRT1 activator (175%, AC50=36.8 uM), directly binds SIRT1 and protects SIRT1 from thermal degradation.
PC-49248

JYQ-42

SIRT6 inhibitor

JYQ-42 is a potent, selective SIRT6 allosteric inhibitor, effectively inhibits SIRT6 deacetylation with IC50 of 2.33 uM, inhibits the deacetylation activity of SIRT6 in pancreatic cancer cell lines.
PC-49081

MC3138

SIRT5 activator

MC3138 is a potent and selective small-molecule SIRT5 activator, inhibits proliferation in SIRT5-low PDAC cell lines and organoids.
PC-47061

SRT2104

SIRT1 activator

SRT2104 (GSK2245840) is a highly selective small molecule activator of the NAD+ dependent deacetylase SIRT1.
PC-38584

SIRT6 activator 12q

SIRT6 activator

SIRT6 activator 12q (Compound 12q) is a potent, selective SIRT6 activator with EC1.5 value of 0.58 μM and EC50 value of 5.35 μM against SIRT6-dependent peptide deacetylation in FLUOR DE LYS assay.
PC-38580

SIRT6 activator CL5D

SIRT6 activator

SIRT6 activator CL5D is a novel small-molecule activator of SIRT6 deacetylation, stimulates 4-fold activation of SIRT6 (1 uM) against H3K9ac (20 uM) at 3 uM.
PC-38543

AGK2

SIRT2 inhibitor

AGK2 is a cell-permeable, selective inhibitor of SIRT2 with IC50 of 3.2 uM, shows minimally affects either SIRT1 or SIRT3 at 10-fold higher levels.
PC-38474

4-bromo-Resveratrol

SIRT1/3 inhibitor

4'-bromo-resveratrol (4'-BR) is a dual small molecule inhibitor of SIRT1 and SIRT3, inhibits melanoma cell growth through mitochondrial metabolic reprogramming.

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