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Cat. No. Product Name Information
PC-21414

TP-0184

ALK2 inhibitor

Itacnosertib (TP-0184) is a novel potent, selective inhibitor of type I bone morphogenetic protein (BMP) receptor ACVR1 (activin A receptor-type 1, ALK2) and FLT3 with IC50 of 8.0 nM (ALK2).
PC-21392

NUCC-555

Activin inhibitor

NUCC-555 is a selective antagonist of Activin antagonist, shows dose-dependent antagonistic activity against activin A-stimulated FSHβ promoter activation in 338FSHβ-luc LβT2 cells with IC50 of 3.67 uM.
PC-49711

CDD-1115

BMPR2 inhibitor

CDD-1115 (CDD1115) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.8 nM and Kiapp of 6.2 nM.
PC-49710

CDD-1653

BMPR2 inhibitor

CDD-1653 (CDD1653) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 2.8 nM, >360-fold over ALK1, and is inactive versus all other type 1 and type 2 TGFβ family kinases.
PC-49709

CDD-1281

BMPR2 inhibitor

CDD-1281 (CDD1281) is a potent, selective inhibitor of BMP type 2 receptor BMPR2 with IC50 of 1.2 nM and Kiapp value of 8 nM.
PC-49109

SY-LB-35

BMP receptor agonist

SY-LB-35 is a highly effective small molecule full agonist of bone morphogenetic protein (BMP) receptor signaling, significantly increases the cell number and cell viability in the C2C12 myoblast cell line.
PC-72935

C381

Smad activator

C381 (SRI011381) is a first-in-class, CNS bioactive compound capable of restoring lysosomal function with prominent antiinflammatory and neuroprotective activities.
PC-72619

PF-06952229

TGFbR1 inhibitor

PF-06952229 (MDV6058) is a potent, selective and orally active TGFBR1 (ALK5) inhibitor with IC50 of 24 nM.
PC-72168

BMS-986260

TGFβR1 inhibitor

BMS-986260 (BMS 986260) is a potent, selective, and orally bioavailable TGFβR1 inhibitor with IC50 of 1.6 nM, negligible inhibition against TGFβR2 (IC50>15 uM).
PC-35812

AZ12799734

BMP/TGFβ inhibitor

AZ12799734 (AZ-12799734) is a pan BMP/TGFβ inhibitor that potently inhibits ligand activated SMAD3/4 transcription with IC50 of 47 nM.
PC-35811

AZ12601011

TGFBR inhibitor

AZ12601011 (AZ-12601011) is a potent, selective inhibitor of ALK4, ALK7 and TGFBR1 (Kd=2.9 nM), inhibits TGFβ-induced reporter activity with IC50 of 18 nM.
PC-35519

BLU-782

ALK2 inhibitor

Fidrisertib (BLU-782) is a potent, selective inhibitor of ALK2 (ACVR1) mutant R206H with IC50 of <10 nM.

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