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Cat. No. Product Name Information
PC-49619

XL388

mTOR inhibitor

XL388 (XL-388) is a potent, selective and orally bioavailable mTOR inhibitor with IC50 of 9.9 nM.
PC-49618

RMC-6272

mTORC1 inhibitor

RMC-6272 (RMC6272) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.44 nM for p4EBP1 inhibition, 27-fold selectivity over mTORC2.
PC-49617

RMC-5552

mTORC1 inhibitor

RMC-5552 (RMC5552) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.48 nM for p4EBP1 inhibition, 40-fold selectivity over mTORC2.
PC-49337

NV-5297

mTORC1 activator

NV-5297 (NV5297) is a novel small molecule mTORC1 pathway activator, modulates the Sestrin2-Gator2 interaction and activates the mTORC1 pathway in vitro and in vivo.
PC-38333

BC-LI-0186

LeuRS inhibitor

BC-LI-0186 is a potent, specific inhibitor of Leucyl-tRNA synthetase (LRS), inhibits the leucine-dependent mTORC1 pathway.
PC-38176

NV-5138

mTORC1 activator

NV-5138 (NV5138) is the first selective, orally bioavailable brain mTORC1 activator, binds to Sestrin2 (Kd=1.5 uM) and activates mTORC1 both in vitro and in vivo.
PC-36112

MTI-31

mTOR inhibitor

MTI-31 (LXI-15029, mTOR inhibitor-31) is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G.
PC-35518

ICSN3250 hydrochloride

mTOR inhibitor

ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
PC-35517

ICSN3250

mTOR inhibitor

ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
PC-63577

GPI-1046

FKBP12 ligand

GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12.
PC-43497

Sapanisertib

mTORC1/2 inhibitor

Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms.
PC-43313

Torin2

mTOR inhibitor

Torin2 is a potent, selective, orally available inhibitor of mTOR, inhibits mTORC1-dependent T389 phosphorylation on S6K with IC50 of 0.25 nM, exhibits 800-fold selectivity over PI3K, and >100-fold over 440 other protein kinases.

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