| Cat. No. |
Product Name |
Information |
| PC-49217 |
UCI-LC0019
|
UCI-LC0019 is a specific small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H. |
| PC-49216 |
UCI-LC0023
|
UCI-LC0023 is a small molecule that restores mutant p53 activity by targeting the cryptic L1/S3 pocket of p53, directly binds to mutant p53 and restores wild-type-like conformation of mutant p53R175H. |
| PC-49198 |
Morncide
|
Morncide (Morn3 (222-237)) is a cell-penetrating, 16-AA Morn3-targeting peptide that disrupts the interaction between p53 and Morn3-mediated complex, Morncide peptide stabilizes and reactivates p53 in cancer cells. |
| PC-49087 |
BAY 249716
|
BAY 1892005 is a small molecule that modulate mutant p53 condensation, showed significant stabilization of all three p53 protein variants, p53WT p53R175H and p53Y220C, exhibits anti-proliferative activity in a set of cell lines with different p53 mutation status with low-uM IC50 values. |
| PC-72829 |
ALRN-6924
|
ALRN-6924 (ALRN6924) is a potent dual inhibitor of MDM2/MDMX. |
| PC-72590 |
ReACp53
|
ReACp53 is a cell-penetrating 17-residue peptide designed to inhibit p53 amyloid formation, rescues p53 function in cancer cell lines. |
| PC-72589 |
ADH-6
|
ADH-6 is a small molceule that abrogates amyloid formation of aggregation-prone region of mutant p53 DBD with binding Ki of 366 nM (p53 mutant R248W DBD-derived peptide, pR248W). |
