| Cat. No. |
Product Name |
Information |
| PC-22005 |
Davelizomib
Proteasome inhibitor
|
Davelizomib is a proteasome inhibitor with antineoplastic effect. |
| PC-21188 |
TCL-1
Rpn-13 inhibitor
|
TCL-1 is non-covalent inhibitor of the Pru (Pleckstrin-like receptor for ubiquitin) domain of Rpn-13, affects proteasome-mediated proteolysis. |
| PC-21187 |
KDT-11
Rpn-13 inhibitor
|
KDT-11 is a specific, reversible peptidomimetic binder inhibitor of Rpn-13 with binding KD of 3 uM, selectively inhibit proliferation of a broad range of cancer cell lines (NCI60, IC50=5 uM), but not non-malignant cells. |
| PC-20757 |
BT317
LonP1 inhibitor
|
BT317 is a small molecule dual inhibitor of mitochondrial Lon Peptidase 1 (LonP1) and CT-L proteasome, subsequently induces ROS accumulation and autophagy-dependent cell death in high-grade IDH1 mutated astrocytoma lines. |
| PC-49521 |
WZ-1831
β5c inhibitor
|
WZ-1831 is a potent and highly selective inhibitor of human constitutive proteasome chymotryptic activity (β5c) with IC50 of 10 nM, >500-fold selectivity over β5i (IC50=7.1 uM). |
| PC-49415 |
Compound 14-100
Hsp70 inhibitor
|
Compound 14-100 is a small molecule, orally active inhibitor targeting pancreatic cancer cell chemotaxis in vitro and in vivo, inhibits Hsp70 coding genes. |
| PC-47062 |
TXS-8
Rpn6 binder
|
TXS-8 is a specific, small molecule binder of Rpn-6 with KD of 14 uM, Rpn-6 is a subunit of the 19S regulatory particle (RP) of 26s proteasome. |
| PC-38434 |
Zetomipzomib
LMP7/LMP2 inhibitor
|
Zetomipzomib (KZR-616) is a first-in-class inhibitor of immunoproteasome, dually inhibits immunoproteasome subunits LMP7 (IC50, 39/57 nM, hLMP7/mLMP7) and LMP2 (IC50, 131/179 nM, hLMP2/mLMP2). |
| PC-72569 |
CBK006377
UPS inhibitor
|
CBK006377 (CBK77) is a small molecule inhibitor of the ubiquitin-proteasome system (UPS) with EC50 of 4.3 uM in MelJuSo Ub-YFP cells (6h treatment). |
| PC-72402 |
M3258
LMP7 inhibitor
|
M3258 (M 3258) is a potent, reversible, highly selective and orally acitve LMP7 inhibitor with cellular IC50 of 4.1 nM. |
| PC-35491 |
TCH-165
Proteasome modulator
|
TCH-165 is a specific small molecule modulator of proteasome assembly, regulates the dynamic equilibrium between the 20S and 26S proteasome complexes, favoring 20S-mediated protein degradation. |
| PC-43439 |
MG-132
Proteasome inhibitor
|
MG-132 (Z-Leu-leu-leu-al, Zlllal) is a potent, reversible, and cell-permeable proteasome inhibitor with IC50 of 0.1 and 1.2 μM for the inhibition of proteasome and calpain, respectively. |
