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Cat. No. Product Name CAS No. Information
PC-35445

Danicopan

1903768-17-1 Danicopan (ACH-4471, ACH-0144471) is a highly potent, orally active Factor D inhibitor with Kd of 0.54 nM, inhibits the proteolytic activity of purified Factor D against substrate Factor B in complex with C3b, blocking production of Bb fragment IC50 of 15 nM.
PC-61821

NDT 9513727

439571-48-9 NDT 9513727 is a potent, selective and orally bioavailable C5a receptor inverse agonist with IC50 of 11.6 nM in radioligand binding assay.
PC-60253

Leukadherin 1

344897-95-6 Leukadherin 1 (LA1) is a small molecule allosteric agonist of integrin CD11b/CD18 (CR3), increases CD11b/CD18-dependent cell adhesion to fibrinogen (EC50=4 uM).
PC-60245

Avacopan

1346623-17-3 Avacopan (CCX-168, CCX168) is a potent, selective, orally availale C5aR (CD88) inhibitor with IC50 of 0.1 nM.
PC-45881

BCX-1470

217099-43-9 BCX-1470 (BCX1470) is a serine protease inhibitor that inhibits the esterolytic activity of factor D (IC50=96 nM) and C1s (IC50=1.6 nM).
PC-38846

W545011

405098-33-1 W-54011 (W54011) is a potent, selective, orally active and non-peptide C5a receptor antagonist, inhibits the binding of 125I-labeled C5a to human neutrophils with Ki of 2.2 nM.
PC-38845

PMX205

514814-49-4 PMX205 is a potent, selective C5a receptor peptide antagonist with IC50 of 30 nM.

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