| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-72246 |
GSK3482364
|
2170136-65-7 |
GSK3482364 (GSK348236428) is a selective, reversible, orally active inhibitor of DNMT1 with IC50 of 0.4 uM, >375-fold selectivity over DNMT3A/3L and DNMT3B/3L (IC50>150 uM). |
| PC-36114 |
Bobcat339
|
2280037-51-4 |
Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
| PC-35290 |
MC3343
|
1535187-91-7 |
MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively. |
| PC-43810 |
SGI-1027
|
1020149-73-8 |
SGI-1027 (SGI1027) is a potent inhibitor of DNA methyltransferase (DNMT) with IC50s of 6-12.5 uM for DNMT1, DNMT3A, and DNMT3B. |
| PC-49682 |
NSC232003
|
1905453-18-0 |
NSC232003 is a small molecule inhibitor of ubiquitin-like protein UHRF1, bind the 5-methylcytosine pocket of UHRF1 and inhibit its functionality, reduces DNMT1/UHRF1 interactions in U251 glioma cells with IC50 of 15 uM, induces global DNA cytosine demethylation. |
| PC-49681 |
UF146
|
5397-78-4 |
UF146 (UF-146) is a specific small molecule inhibitor of ubiquitin-like protein UHRF1, binds with the SRA domain groove of UHRF1 with KD of 3.71 uM, significantly inhibits the binding of UHRF1 and hemi-methylated DNA with IC50 of 499.4 nM in FRET assays. |
| PC-38486 |
SW155246
|
420092-79-1 |
SW155246 is a potent, selective antagonis/inhibitor of DNA methyltransferase DNMT1 with IC50 of 1.2 uM against hDNMT1, 30-fold preference versus human or murine DNMT3A or -3B (IC50=38 uM). |
