| Cat. No. |
Product Name |
Information |
| PC-38044 |
EDP-305
FXR agonist
|
EDP-305 (EDP305) is a potent, selective, nonbile acid farnesoid X receptor (FXR) agonist with EC50 of 34 nM, shows antifibrotic effect. |
| PC-43034 |
INT-767
FXR/TGR5 agonist
|
INT-767 (INT767) is a potent, selective, dual farnesoid X receptor (FXR) and TGR5 agonist with EC50 of 30 and 630 nM, respectively. |
| PC-63021 |
MFA-1
FXR agonist
|
MFA-1 (Merck FXR agonist 1) is a potent, synthetic FXR agonist with EC50 of 16.9 nM in coactivator recruitment assays, displays 500-fold more potent than CDCA. |
| PC-61390 |
Nidufexor
FXR agonist
|
Nidufexor (LMB763, LMB-763) is a potent, selective, non-bile acid partial agonist of farnesoid X receptor (FXR) with EC50 of 7 nM in FXR-HTRF biochemical assay measuring the ligand-induced interaction between FXR and the Steroid Receptor Coactivator-1 (SRC1). |
| PC-61368 |
Cilofexor
FXR agonist
|
Cilofexor (GS-9674, GS9674, PX-104) is a potent, specific, non-steroidal farnesoid X receptor (FXR) agonist with EC50 of 43 nM. |
| PC-61057 |
DM509
FXR agonist, sEH inhibitor
|
DM509 is a potent, orally active dual modulator of FXR and soluble epoxide hydrolase (sEH) that exertss partial FXR agonism (pEC50=7.7) and sEH inhibitory activity (pIC50=8.4). |
| PC-60080 |
GSK-2324
FXR agonist
|
GSK-2324 (GSK2324) is a potent, selective, full FXR agonist with EC50 of 120 nM in FRET assay. |
| PC-60079 |
LY-2562175
FXR agonist
|
LY-2562175 (LY2562175, LY 2562175) is a novel potent, selective, partial FXR agonist with EC50 of 193 nM. |
| PC-60056 |
Tropifexor
FXR agonist
|
Tropifexor (LJN-452, LJN452) is a novel highly potent, selective, orally acitive FXR full agonist with EC50 of 0.26 nM. |
| PC-42734 |
Fexaramine
FXR agonist
|
Fexaramine is a potent, specific FXR agonist with EC50 of 25 nM, more efficacious ligand for FXR than GW4064. |
| PC-45980 |
Chenodeoxycholic Acid
FXR agonist
|
Chenodeoxycholic Acid (CDDA) is a potent natural bile acid at stimulating the nuclear bile acid receptor, farnesoid X receptor (FXR). |
| PC-45825 |
GW-4064
FXR agonist
|
GW-4064 (GW4064) is a potent and selective FXR agonist with EC50 of 15 nM in cell-free assay, >200-fold more potent than CDCA. |
