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Cat. No. Product Name Information
PC-20622

ICG-001

TCF/beta-catenin inhibitor

ICG-001 (ICG001) is a specific small molecule inhibitor of TCF/beta-catenin, antagonizes β-catenin/TCF-mediated transcription with IC50 of 3 uM.
PC-20175

IMU1003

Wnt/β-catenin inhibitor

IMU1003 (IMU-1003) is a small molecule inhibitor of Wnt/β-catenin signaling, decreases β-catenin levels and inhibits target gene expression that promotes cancer cell proliferation.
PC-38652

PTK7/β-catenin inhibitor 01065

PTK7/β-catenin inhibitor

PTK7/β-catenin inhibitor 01065 is a small molecule inhibitor of PTK7/β-catenin interaction (IC50=8.9 uM) targeting the Wnt pathway signaling, induces antiproliferative and antitumor effects in vitro in CRC cells harboring β-catenin or adenomatous polyposis coli (APC) mutations.
PC-38567

E722-2648

β-catenin/BCL9 inhibitor

E722-2648 (Compound C-1) is a novel specific and competitive small molecule β-catenin/BCL9 interaction inhibitor with ITC KD of 1.05 uM and IC50 of 9 uM, blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer.
PC-38409

Miclxin

MIC60 inhibitor

Miclxin (DS37262926) is a small molecule inhibitor of MICOS component MIC60, induces mitochondrial stress response in a mutant β-catenin-dependent manner in β-catenin-mutated HCT116 cells, directly binds to mitochondrial inner membrane complex protein MIC60 (SPR Kd=11.9 uM).
PC-73231

GB1874

Beta-catenin-TCF4 inhibitor

GB1874 is an inhibitor of the Wnt pathway that targets the β-catenin-TCF4 interaction.
PC-73060

RX-5902

P-p68 inhibitor

RX-5902 (Supinoxin, RX5902) is a small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68) and attenuates nuclear shuttling of β-catenin.
PC-72708

ZW4864

BCL9/β-catenin inhibitor

ZW4864 (ZW-4864) is an orally bioavailable small-molecule that binds with β-catenin and selectively disrupts the PPI between BCL9 and β-catenin, while sparing the β-catenin/E-cadherin PPI.
PC-72072

β-catenin inhibitor C2

β-catenin inhibitor

β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.
PC-35350

SKL2001

Axin/β-catenin inhibitor

SKL2001 is a specific small molecule activator (agonist) of the Wnt/β-catenin pathway, stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction.
PC-35329

E-7386

CBP/beta-catenin inhibitor

E-7386 (E7386) is a potent, orally active modulator of CBP/beta-catenin, disrupts the interaction and inhibits canonical Wnt signaling pathway /TCF reporter gene activity in LiCl-stimulated HEK-293 and MDA-MB-231 with IC50 of 55 and 73 nM, respectively.
PC-62707

β-catenin-IN-11a

β-catenin inhibitor

β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex.

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