| Cat. No. |
Product Name |
Information |
| PC-27902 |
RK447
RAS/RAF inhibitor
|
RK447 is a specific small-molecule RAS/RAF inhibitor that specifically binds to CRAF RAS binding domain (RBD), allosterically disrupts RAS/RAF binding, exhibits potent HRAS/CRAF binding inhibition in ELISA with IC50 of 1.15 uM. |
| PC-27901 |
RK440
RAS/RAF inhibitor
|
RK440 is a specific small-molecule RAS/RAF inhibitor that specifically binds to the CRAF RBD, allosterically disrupts RAS/RAF binding, exhibits potent HRAS/CRAF binding inhibition in ELISA with IC50 of 1.41 uM. |
| PC-27900 |
Kobe3708
RAS/RAF inhibitor
|
Kobe3708 is a small-molecule RAS/RAF inhibitor that specifically binds to the CRAF RBD but not to RAS, allosterically disrupts RAS/RAF binding, inhibits the binding between HRASG12V·GTP and CRAF RBD in ELISA with IC50 of 7.62 uM. |
| PC-27489 |
LUT014
BRAF inhibitor
|
Omzirafenib (LUT014, LUT-014) is a potent and specific, topical BRAF kinase inhibitor with IC50 of 13.3 nM and 11.7 nM for BRAF-V600E and WT BRAF respectively, paradoxically activates mitogen-activated protein kinase (MAPK). |
| PC-26493 |
PHI-501
RAF/DDR inhibitor
|
PHI-501 is a potent dual inhibitor of RAF and DDR1/2 with IC50 of 0.30 nM for DDR1 and 8.57 nM for DDR2, inhibits ARAF, BRAF, BRAF V600E, CRAF, and additional BRAF V600 variants (V600A/D/E/K, G464V, and L597V) with IC50 of 1.5-27.8 nM. |
| PC-25949 |
TWG-07-148
ARAF-MEK inhibitor
|
TWG-07-148 is a potent, covalent ARAF-MEK inhibitor with IC50 of 5.5 nM in biochemical ARAF-MEK assays, binds irreversibly to Cys514 on ARAF. |
| PC-24572 |
Dabrafenib
BRAF V600E inhibitor
|
Dabrafenib (GSK2118436) is potent, selective ATP-competitive inhibitor of Raf with IC50 of 5 nM and 0.6 nM for C-Raf and B-Raf V600E respectively, also potently inhibits RIPK3 with IC50 of 28 nM. |
| PC-22523 |
PF-07799933
mutant BRAF inhibitor
|
PF-07799933 (Claturafenib, ARRY-440) is a brain-penetrant, selective, pan-mutant BRAF inhibitor, demonstrated broad inhibition of pERK levels in cell lines harboring Class I (IC50=0.7-7 nM), II (10-14 nM), III (0.8, 7.8 nM), and indel (113, 179 nM) mutations, acquired BRAF p61 splice variant (59 nM), and acquired NRAS-Q61K (16 nM), but significantly spared pERK in BRAF wild-type cells (≥9800 nM). |
| PC-22122 |
NST-628
RAF-MEK molecular glue
|
NST-628 is a potent, brain-penetrant, pan-RAF-MEK molecular glue, prevents phosphorylation and activation of MEK by RAF, leading to deep durable inhibition of MEK kinase activity and downstream ERK signaling. |
| PC-21593 |
Erianin
Raf-MEK inhibitor, Pyruvate carboxylase inhibitor
|
Erianin is a small molecule inhibitor of CRAF and MEK1/2 kinases, inhibits constitutive activation of MAPK signaling pathway, potent inhibits pyruvate carboxylase (PC) with IC50 of 5 nM. |
| PC-21386 |
Uplarafenib
BRAF inhibitor
|
Uplarafenib is a potent, selective small molecule inhibitor of BRAF kinase (IC50=50-100 nM) with antineoplastic activities. |
| PC-21219 |
Exarafenib
pan-RAF inhibitor
|
Exarafenib (KIN-2787) is a highly potent and selective pan-RAF inhibitor with IC50 of 2.4/3.5/1.4 nM for ARAF/BRAF/CRAF, respectively. |
