| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-60991 |
AS2677131
|
2171502-44-4 |
AS2677131(AS 2677131, AS-2677131) is a novel potent, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=4 nM). |
| PC-47004 |
PIKfyve inhibitor WX8
|
1164477-46-6 |
WX8 is a specific inhibitor of PIKfyve, induces accumulation of cytoplasmic vacuoles on osteosarcoma U2OS cells with EC50 of 10 nM. |
| PC-47003 |
HZX-02-059
|
2240205-30-3 |
HZX-02-059 is a PIKfyve and tubulin dual-target inhibitor with high affinity for PIKfyve (Kd=10.4 nM), HZX-02-059 is a potent methuosis inducer, shows both in vitro and in vivo anti-tumor activity against TNBC. |
| PC-47002 |
APY0201
|
1232221-74-7 |
APY0201 is a potent, highly selective, ATP-competitive PIKfyve inhibitor with IC50 of 5.2 nM, displays broad anti-multiple myeloma activity with EC50 at nanomolar concentrations. |
| PC-43409 |
YM-201636
|
371942-69-7 |
YM-201636 is a potent, selective PIKfyve inhibitor with IC50 of 33 nM, does not inhibits type Iiγ/Iα PtdInsP kinases even at 10 uM (p110α IC50=3.3 uM). |
| PC-60992 |
AS2795440
|
|
A novel potent, selective, oral PIKfyve inhibitor that selectively decreases c-Rel binding to gene promoters of IL-12p40 and IL-1β, regulates cytokine production through PIKfyve-c-Rel pathway ( IL-12p40 IC50=2 nM). |
| PC-60412 |
Apilimod
|
541550-19-0 |
A potent IL-12/IL-23 inhibitor that down-regulates both IL-12 p35 and IL-12/IL-23 p40 at the transcriptional level, and inhibits the production of both IL-12 and IL-23 cytokines (IC50=2 nM). |
