| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-42142 |
MLi-2
|
1627091-47-7 |
MLi2 is a potent, selective, orally available and brain-penetrant LRRK2 inhibitor with kinase IC50 of 0.76 nM, cellular IC50 of 1.4 nM (dephosphorylation of LRRK2 pSer935 LRRK2). |
| PC-45425 |
GNE-7915 tosylate
|
2070015-00-6 |
GNE-7915 tosylate (GNE7915 tosylate) is a highly potent, selective, and brain-penetrable LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-45424 |
GNE-7915
|
1351761-44-8 |
A highly potent, selective, and brain-penetrant LRRK2 inhibitor with IC50 of 1.9 nM. |
| PC-49826 |
Lu AF58786
|
1632368-13-8 |
Lu AF58786 is a potent and selective LRRK2 inhibitor with IC50 of 12 nM, 19 nM and 93 nM for LRRK2 WT, LRRK2-G2019S and LRRK2-A2016T in cell-based assays, respectively. |
| PC-49823 |
LRRK2 inhibitor 25
|
2307277-93-4 |
LRRK2 inhibitor 25 is a potent, selective, CNS-penetrant and ATP competitive LRRK2 inhibitor with biochemical IC50 of 0.9 nM, cellular IC50 of 0.3 nM. |
| PC-49822 |
LRRK2 GTP binding inhibitor 68
|
947086-88-6 |
LRRK2 GTP binding inhibitor 68 is a potent, GTP binding inhibitor of LRRK2 with IC90 of 10 nM, inhibits LRRK2 GTP binding and kinase activities. |
| PC-49821 |
FX2149
|
1842427-90-0 |
FX2149 (FX 2149) is a potent, BBB permeable inhibitor of LRRK2 GTP binding activity with IC90 of 10 nM, reduces PD-linked mutant LRRK2 variants (G2019S and R1441C) that bound with GTP. |
