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Cat. No. Product Name Information
PC-21965

PT-179

CRBN ligand

PT-179 is a selective molecular glue and thalidomide derivative, binds CRBN with a Kd of 587 nM, does not induce degradation of known pomalidomide neosubstrates.
PC-20467

Lenalidomide

CRBN ligand

Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue for PROTAC design, Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN), and causes selective ubiquitination and degradation of IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase.
PC-49083

Z0933M

Skp1 inhibitor

Z0933M is a potent S phase kinase-associated protein 1 (Skp1) inhibitor with Kd of 54 nM, potently inhibits Skp1-F-box protein-protein interactions with Ki value of 231 nM in FP-based in vitro competition assays.
PC-38766

NJH-2-030

FEM1B E3 ligand

EN106 derivative 3 is a EN106 derivative used for PROTAC design, EN106 is a covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation.
PC-38760

EN106

FEM1B ligand

EN106 is a cysteine-reactive covalent ligand and recruiter for FEM1B E3 ligase for targeted protein degradation, PROTAC linking EN106 to the BET bromodomain inhibitor JQ1 or the kinase inhibitor dasatinib leads to the degradation of BRD4 and BCR-ABL, respectively.
PC-38610

VL285

VHL ligand

VL285 is a potent VHL ligand that degrades HaloTag7 fusion proteins, attenuates the ability of HaloPROTAC3 to induce the degradation of GFP-HaloTag7 (IC50=0.34 uM).
PC-38591

BTX306

Protein homeostatic modulator

BTX306 (BTX-306) is a novel protein homeostatic modulator, potently reduces levels of GSPT1, eRF1, CK1α, MCL-1, and c-MYC in myeloma cells, overcomes bortezomib and lenalidomide resistance.
PC-38389

Eragidomide

GSPT1 degrader

Eragidomide (CC-90009) is a first-in-class, GSPT1-selective cereblon E3 ligase modulator, selectively degrades GSPT1 (EC50=9 nM) resulting in acute AML apoptosis and elimination of disease-driving leukemia stem cells (LSCs).
PC-73229

EN219

RNF114 ligand

EN219 is a fully synthetic covalent ligand that targets RNF114, recruites the E3 ubiquitin ligase RNF114 for targeted protein degradation.
PC-38086

Mezigdomide

Cereblon modulator

Mezigdomide (CC-92480) is a novel cereblon E3 ubiquitin ligase modulator (CELMoD) with high affinity to cereblon, resulting in potent antimyeloma activity.
PC-38042

WUN29654

CRBN modulator

WUN29654 is a thalidomide analog and a CRBN modulator with IC50 of 3.5 uM and Ki of 0.98 uM for CRBN binding.
PC-61056

VH298

VHL E3 ubiquitin ligase inhibitor

VH 298 is a potent, specific cell-active VHL E3 ubiquitin ligase inhibitor that inhibits VHL/HIF-α interaction with Kd of 90 nM in ITC assays.

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