| Cat. No. |
Product Name |
Information |
| PC-28197 |
METTL1 inhibitor B22
METTL1 inhibitor
|
METTL1 inhibitor B22 is a specific small molecule inhibitor of RNA methyltransferase METTL1 with IC50 of 1 uM, selective against a panel of 7 HMTases and the RNA-methyltransferase METTL3/METTL14. |
| PC-28196 |
EZM8266
G9a inhibitor
|
EZM8266 is a potent, selective and orally active G9a (histone lysine methyltransferase 2, EHMT2) inhibitor with IC50 of 1 pM for human EHMT2, effectively reduces H3K9me2 levels. |
| PC-28173 |
TRDMT1i
TRDMT1 inhibitor
|
TRDMT1i (YW1842, YW-1842) is a potent small molecule inhibitor of RNA methyltransferase TRDMT1, blocks TRDMT1-mediated m5C formation in DNA-RNA hybrids in vitro and reduces the viability of cancer cell lines. |
| PC-28117 |
TR-07 hydrochloride
PRMT1 activator
|
PRMT1 activator TR-07 hydrochloride is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro. |
| PC-28112 |
PRMT1 activator TR-07
PRMT1 activator
|
PRMT1 activator TR-07 is a selective, cell-active PRMT1 activator with EC50 of 208.3 uM, selectively enhances the catalytic activity of PRMT1 in vitro. |
| PC-28089 |
LEM-06
NSD2 inhibitor
|
LEM-06 is a small molecule inhibitor of histone methyltransferase NSD2 with IC50 of 0.8 mM against H3K36 methylation in vitro. |
| PC-28088 |
NSD2 inhibitor PTD2
NSD2 inhibitor
|
NSD2 inhibitor PTD2 is a peptide derived from histone H4 sequence and inhibitor for the histone methyltransferase WHSC1 (Nuclear receptor-binding SET domain protein 2, NSD2, MMSET) with SPR KD of 3.0 uM, IC50 of 22 uM and 3.2 uM for NSD2 and NSD3 respectively. |
| PC-28070 |
AZD3632
Menin inhibitor
|
AZD3632 (AZD-3632) is a potent, selective and orally active second-generation menin inhibitor, disrupts the Menin-KMT2A complex, suppresses leukemogenic transcription and promotes malignant cell differentiation. |
| PC-27974 |
LC-YD17
YTHDC1 inhibitor
|
LC-YD17 is a potent, selective YTH domain-containing protein 1 (YTHDC1) inhibitor with IC50 of 107.12 nM, exhibits growth inhibitory activity in MOLM-13 and THP-1 cells with IC50 of 11.74 and 16.36 uM respectively. |
| PC-27973 |
LC-YD03
YTHDC1 inhibitor
|
LC-YD03 is a potent, selective YTH domain-containing protein 1 (YTHDC1) inhibitor with IC50 of 41.98 nM and BLI Kd of 102 nM, shows little to no activity against YTHDF1, YTHDF2, YTHDF3, and YTHDC2. |
| PC-27909 |
AL398
NSUN6 inhibitor
|
AL398 is a specific small molecule inhibitor of m5C methyltransferase NSUN6 with IC50 of 2.796 uM, shows negligible effects on the stability of other methyltransferases, including NOP2, NSUN2, and METTL3. |
| PC-27906 |
AN465
EV71 inhibitor, METTL3 inhibitor
|
AN465 (AN-465/42162872) is a potent inhibitor of Enterovirus 71 (EV71) with EC50 of 18.48 uM, effectively inhibits m6A methyltransferase METTL3 with IC50 of 1.782 uM and KD of 8.75 uM. |
