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Cat. No. Product Name Information
PC-21286

VCP Activator 1

VCP/p97 activator

VCP Activator 1 (VA1) is a small molecule allosteric activator of valosin-containing protein (VCP)/p97, dose-dependently stimulates VCP ATPase activity up to 3-fold (EC50= 4 uM).
PC-49108

NW1030

p97 modulator

NW1030 is a small molecule that target the regulatory domain of VCP/p97, increases the degradation of a p97-dependent reporter, does not affect the main catalytic domain of p97.
PC-49107

NW1028

p97 modulator

NW1028 is a small molecule that target the regulatory domain of VCP/p97, inhibits the degradation of a p97-dependent reporter, does not affect the main catalytic domain of p97.
PC-38720

OSSL_325096

p97/VCP inhibitor

OSSL_325096 is a novel potent small mlolecule p97/VCP inhibitor, suppresses cell proliferation and induces ER stress and apoptotic cell death in MM cell lines (IC50=0.1-0.5 uM).
PC-38468

NMS-873

p97/VCP inhibitor

NMS-873 (NMS873) is a potent, specific, cell-permeable, non-ATP competitive, allosteric inhibitor of VCP/p97 ATPase with IC50 of 30 nM.
PC-72870

FL-18

p97 inhibitor

FL-18 (p97 inhibitor FL-18) is is the first small-molecule covalent inhibitor of VCP/p97 AAA ATPase with IC50 of 59.3 nM, capable of covalent engagement of p97 with proteome-wide selectivity.
PC-72409

CB5339

VCP/p97 inhibitor

CB5339 (CB-5339) is a second-generation, potent, selective, ATP-competitive, and oral inhibitor of valosin-containing protein (VCP/p97) with IC50 of 9 nM.
PC-36136

LC-1028

p97/VCP inhibitor

LC-1028 (LC1028) is a novel potent selective, covalent and irreversible inhibitor of p97 (valosin-containing protein), remains essentially irreversible ac tivity against p97 mutant C522A..
PC-35960

NPD8733

p97 inhibitor

NPD8733 (NPD-8733) is a small-molecule ligand of valosin-containing protein (VCP)/p97, binds to the D1 domain of VCP/p97.
PC-63243

UPCDC30245

p97/VCP inhibitor

UPCDC-30245 is a potent, cell penetrant allosteric p97/VCP inhibitor with IC50 of 300 nM (WT p97), also potently inhibits CB-5083 resistant p97 D649A/T688A mutant.
PC-43263

CB-5083

p97 inhibitor

CB-5083 is a potent, selective, orally bioavailable inhibitor of p97 AAA with IC50 of 11 nM, specifically targets D2 ATPase site of p97, shows 9.6, 128 and 158-fold less affinity for DNA-PK, mTOR and PIK3C3.
PC-62542

MSC 1094308

VCP/p97 inhibitor

MSC1094308 (MSC 1094308) is a reversible, allosteric inhibitor of the type II AAA ATPase human ubiquitin-directed unfoldase (VCP)/p97 and the type I AAA ATPase VPS4B with IC50 of 7.2 and 0.71 uM, respectively.

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