| Cat. No. |
Product Name |
Information |
| PC-21407 |
YAK540
class IIa HDAC inhibitor
|
YAK540 is a potent, highly selective class IIa HDAC inhibitor with IC50 of 114 nM (HDAC4), displays excellent selectivity against HDAC2 (265-fold), HDAC6 (100-fold), and HDAC8 (82-fold). |
| PC-20992 |
Yanostat
class I HDAC inhibitor
|
Yanostat (KH16) is a novel potent HDAC inhibitor with low nanomolar in vitro activity against class I HDACs (HDAC1/2/3 IC50=13/34/6 nM). |
| PC-20984 |
Citarinostat
HDAC6 inhibitor
|
Carinostat (ACY-241) is a second generation potent, orally active and high-selective HDAC6 inhibitor with IC50 of 2.6 nM. |
| PC-20784 |
Romidepsin
class I HDAC inhibitor
|
Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide) is a natrual produrct from Chromobacterium violaceum as class I HDACs inhibitor, inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1400 nM, respectively. |
| PC-20238 |
RGFP963
HDAC3 inhibitor
|
RGFP963 (RGFP 963) is a potent, selective class I HDAC inhibitor with IC50 of 1.51 uM, 0.75 and 0.096 uM for HDAC1, HDAC2, and HDAC3, respectively. |
| PC-20237 |
RGFP966
HDAC3 inhibitor
|
RGFP966 (RGFP 966) is a potent, specific HDAC3 inhibitor with IC50 of 0.08 uM, without effective inhibition of any other HDACs at 15 uM. |
| PC-20141 |
HDAC10 inhibitor 10c
HDAC10 inhibitor
|
HDAC10 inhibitor 10c is a potent, selective HDAC10 inhibitor with IC50 of 20 nM, shows high specificity over HDAC6 and with no significant impact on class I HDACs. |
| PC-49678 |
YSL-109
HDAC6 inhibitor
|
YSL-109 (YSL109) is a potent, highly selective small molecule inhibitor of HDAC6 with IC50 of 0.537 nM, >4000-fold selectivity over HDAC1 and HDAC8. |
| PC-49452 |
NN-429
HDAC6 inhibitor
|
NN-429 (NN429) is a potent, selective second-generation inhibitor of HDAC6 with IC50 of 3.2 nM, >312-fold selectivityt over all HDAC isoforms. |
| PC-49250 |
TYA-018
HDAC6 inhibitor
|
TYA-018 (TYA018) is a potent, isoform-selective inhibitor of HDAC6 with IC50 of 10 nM, inhibits tubulin acetylation (Ac-Tubulin) with EC50 of 120 nM in cell-based assay in induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs). |
| PC-49104 |
MPT0B390
HDAC1/2 inhibitor
|
MPT0B390 (B390) is a selective HDAC1/2 inhibitor and an effective inducer of metalloproteinase 3 (TIMP3), significantly upregulates TIMP3 expression in colorectal cancer cells. |
| PC-49072 |
KH-259
HDAC6 inhibitor
|
KH-259 is a potent, isozyme-selective and CNS-penetrant HDAC6 inhibitor with IC50 of 260 nM, shows weak activity against HDAC1 and HDAC4 (IC50>6 uM). |
