| Cat. No. |
Product Name |
Information |
| PC-27746 |
HDAC8 inhibitor Compound 3
HDAC8 inhibitor
|
HDAC8 inhibitor Compound 3 is a potent and selective HDAC8 inhibitor with IC50 of 200 nM, does not inhibit HDAC1, HDAC2, HDAC6. |
| PC-27745 |
HDAC8 inhibitor TH42
HDAC8 inhibitor
|
HDAC8 inhibitor TH42 is a potent and selective HDAC8 inhibitor with IC50 of 69 nM. |
| PC-27743 |
OJI-1
HDAC8 inhibitor
|
OJI-1 is a potent, selective HDAC8 inhibitor with IC50 of 0.8 nM, mildly inhibits HDAC6 and HDAC1 with IC50s of 1.2 uM and 4.3 uM, does not inhibit other HDACs. |
| PC-27701 |
CHDI-00484077
class IIa HDAC inhibitor
|
CHDI-00484077 is a selective class IIa HDAC inhibitor with IC50 of 0.01, 0.02, 0.02, and 0.03 uM for HDACX4, 5, 7 and 9 respectively, shows >100-fold selectivity over class I/IIb HDACs. |
| PC-27699 |
MC1742
HDAC inhibitor
|
MC1742 is a potent HDAC inhibitor with IC50s of 0.1 μM, 0.11 μM, 0.02 μM, 0.007 μM, 0.61 μM, 0.04 μM and 0.1 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 and HDAC11, respectively, also potently reactivate HIV from latency. |
| PC-27698 |
MC2590
class I/IIb HDAC inhibitor
|
MC2590 is a selective class I/IIb HDACs inhibitor with IC50 of 0.098, 0.156, 0.039, 0.015 and 0.047 uM for HDAC1, 2, 3, 6 and HDAC8 respectively. |
| PC-27254 |
Taginostat
HDAC6 inhibitor
|
Taginostat is a potent and selective HDAC6 inhibitor with IC50 of 6.9 nM (hHDAC6), >45-fold selectivity over hHDAC1 and hHDAC8, activates the transcription factor STAT4 in CLL cells. |
| PC-27078 |
R306465
HDAC inhibitor
|
R306465 (JNJ-16241199) is a selective, potent inhibitor of class I histone deacetylase (HDACs) with IC50 of 3.31 nM and 23 nM for HDAC1 and HDAC8. |
| PC-26710 |
SP108
HDAC3 inhibitor
|
SP108 is a potent, selective and brain-permeable HDAC3 inhibitor with IC50 of 15.41 nM, shows 18.72-, 34.65-, >100-, >1000-, >1000-, and >1000-fold selectivity over HDAC1, HDAC2, HDAC8, HDAC6, HDAC4, and HDAC5, respectively. |
| PC-26486 |
GV-001
HDAC6 inhibitor
|
GV-001 is a potent, selective and orally bioavailable HDAC6 inhibitor with IC50 of 1.18 nM, shows >200- and 1900-fold selectivity over HDAC1 and HDAC8. |
| PC-26061 |
PTERi
PTER inhibitor
|
PTERi (PTER inhibitor, PTER-IN-1) is a potent, seletive inhibitor of PTER (phosphotriesterase-related) with IC50 of 43 nM (recombinant mouse PTER activity), >100-fold selectivity for PTER over HDACs and sirtuin (SIRT) deacetylases in vitro. |
| PC-25846 |
GCJ-490A
HDAC inhibitor
|
GCJ-490A is a pan-histone deacetylase (HDAC) inhibitor that exerts potent inhibitory activity against HDAC1, HDAC3, and HDAC6 with IC50 of 3.64, 3.02 and 4.96 nM respectively. |
