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Cat. No. Product Name CAS No. Information
PC-49050

AGF94

136784-51-5 AGF94 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis.
PC-49049

AGF154

1286279-90-0 AGF154 is a 6-substituted pyrrolo[2,3-d]pyrimidine thienoyl antifolate with potent antiproliferative activities against tumor cells, with proton-coupled folate transporter (PCFR) and folate receptor (FR) selectivity over the reduced folate carrier (FRC), inhibtis de novo purine nucleotide biosynthesis.
PC-49048

ONX0801

501332-69-0 ONX 0801 (BGC 945) is a small molecule thymidylate synthase (TS) inhibitor, can be selectively transported to tumor cells via α-folate receptor (α-FR, KD=1 nM), but not the physiological reduced-folate carrier system (RFC).
PC-49047

Plevitrexed

153537-73-6 Plevitrexed (ZD 9331, BGC 9331)a reduced-folate carrier system (RFC)-mediated thymidylate synthase inhibitor with Ki of 0.44 nM, selectively binds to the folate binding site of thymidylate synthase and inhibits thymidine synthesis, causes DNA synthesis inhibition and apoptosis.
PC-47090

TH7299

1415648-20-2 TH7299 is a potent mitochondrial inhibitor of mitochondrial MTHFD2L with IC50 of 274 nM, TH7299 is
highly selective towards MTHFD2 (IC50=254 nM) over other enzymes involved in 1C-metabolism (i.e. SHMT1/2, TS and DHFR).
PC-73018

DS18561882

2227149-22-4 DS18561882 (DS 18561882, DS18) is a potent, isozyme-selective, orally available MTHFD2 inhibitor with IC50 of 6.3 nM, >800-fold selectivity over MTHFD1.
PC-73015

DS44960156

2361327-08-2 DS44960156 (DS 44960156) is a isozyme-selective MTHFD2 inhibitor with IC50 of 1.6 uM, without inhibitory effect against MTHFD1 (IC50>30 uM).

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