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Cat. No. Product Name CAS No. Information

SARS-CoV-2 PLpro inhibitor 7

2916374-50-8 SARS-CoV-2 PLpro inhibitor 7 is a potent, selective and covalent inhibitor of SARS-CoV-2 papain-like protease (PLpro) with IC50 of 94 nM, shows SARS-CoV-2 antiviral activity with EC50 of 1.1 uM.

SARS-CoV-2 nsp14 inhibitor 25

2766190-68-3 SARS-CoV-2 nsp14 inhibitor 25 is a highly potent, selective, nucleoside-derived inhibitor of SARS-CoV-2 nsp14 (N7-guanine)-methyltransferase (N7-MTase) with IC50 of 19 nM, no inhibition against human RNA N7-MTase (hRNMT, IC50>50 uM).


2647442-13-3 GS-621763 is an oral prodrug of remdesivir parent nucleoside GS-441524, inhibits SARS-CoV-2, including variants of concern in cell culture (EC50=0.11 to 0.73 uM) and human airway epithelium organoids.


Coranastat (NK01-63) is a GC376 analog with improved potency, and highly potent, selective SARS-CoV-2 3CL protease inhibitor with IC50 of 16 nM, exhibits antiviral potency with EC50 of 6 nM in Huh-7ACE2 cellular assays.

CSNK2A inhibitor 2

2470424-33-8 CSNK2A inhibitor 2 (CK2 inhibitor Compound 2) is a potent, selective, cell active ATP-competitive inhibitor of host protein kinase Casein Kinase 2 (CSNK2A1/2, pIC50=8.5-8.6), inhibits the pathogenic β-coronaviruses including SARS-CoV-2 (MHV pIC50=8.6)


2468015-78-1 PF-07304814 (PF 07304814, Lufotrelvir) is a phosphate prodrug of PF-00835231, which is a potent, selective inhibitor of pan-coronavirus family 3CL pro.


2628280-40-8 PF-07321332 (Nirmatrelvir, Paxlovid) is the first, orally bioavailable SARS-CoV-2 main protease (M pro) inhibitor with biochemical Ki of 3.11 nM.

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