Bacterial compound (inhibitors, antagonists)-ProbeChem.com

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Bacteria constitute a large domain of prokaryoticmicroorganisms. Antibiotics (also called antibacterials) are a type of antimicrobial drug used in the treatment and prevention of bacterial infections, a limited number of antibiotics also possess antiprotozoal activity. Together with vaccination, antibiotics have led to the near eradication of diseases such as tuberculosis in the developed world. However, their effectiveness and easy access have also led to their overuse, prompting bacteria to develop resistance.

A bactericidal activity of antibacterials may depend on the bacterial growth phase, and it often requires ongoing metabolic activity and division of bacterial cells. In vitro characterization of antibacterial activity commonly includes the determination of the minimum inhibitory concentration and minimum bactericidal concentration of an antibacterial. To predict clinical outcome, the antimicrobial activity of an antibacterial is usually combined with its pharmacokinetic profile, and several pharmacological parameters are used as markers of drug efficacy.

Cat. No.	Product Name	Information
PC-25652	JH-LPH-50 LpxH inhibitor	JH-LPH-50 is a highly potent UDP-2,3-diacylglucosamine pyrophosphate hydrolase LpxH inhibitor with Ki of 3.1 nM, and IC50 of 7.7 nM (K. pneumoniae LpxH), shows antibiotic activity with MIC of 3.3 ug/mL for wild-type K. pneumoniae (ATCC 10031).
PC-25641	D-IX216 Mtb RNAP inhibitor	D-IX216 is a potent, selective Mycobacterial RNA polymerase (Mtb RNAP) with IC50 of 100 nM, slows MtbRNAP translocation in a sequence-independent manner.
PC-25640	D-AAP1 Mtb RNAP inhibitor	D-AAP1 is a potent, selective, stereospecific activity against Mycobacterium tuberculosis RNA polymerase (Mtb RNAP) with IC50 of 0.4 uM, shows poor inhibition of other bacterial RNAP and human RNAP I, II, and III.
PC-25241	Ganfeborole hydrochloride Mtb LeuRS inhibitor	Ganfeborole hydrochloride (GSK3036656, GSK656) is a potent, highly selective, orally bioavailable Mtb Leucyl-tRNA synthetase (LeuRS) with IC50 of 0.2 uM.
PC-25077	Mtb LepB inhibitor 17af LepB inhibitor	Mtb LepB inhibitor 17af is a potent, small molecule inhibitor of M. tuberculosis type I signal peptidase (LepB) with IC90 of 0.41 uM for LepB under-expressing (LepB-UE) strain of M. tuberculosis, shows IC50 of 1.2 uM against wild-type Mtb.
PC-24831	ANT3310 sodium Serine β-Lactamase inhibitor	ANT3310 sodium (Pilabactam) is a potent, covalent broad-spectrum serine β-Lactamase inhibitor with IC50 of 1-175 nM against a panel of serine β-Lactamases.
PC-24737	Tarocin A TarO inhibitor	Tarocin A is a specific inhibitor of UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase (TarO) with IC50 of 0.18 uM, inhibits the first step in wall teichoic acid biosynthesis, restore β-lactam efficacy against MRSA.
PC-24403	HilD inhibitor C26 S. Typhimurium HilD inhibitor	HilD inhibitor C26 is a specific small molecule inhibitor of S. Typhimurium transcriptional regulator HilD with IC50 of 16.9 uM and binds to HilD with an apparent Kd of 30.2 uM, inhibits the secretion of SipA with IC50 of 29.2 uM.
PC-24236	FBX-1991 H. pylori FabX inhibitor	FBX-1991 is a potent, specific small molecule inhibitor of Helicobacter pylori (H. pylori) dehydrogenase/isomerase FabX with IC50 of 0.158 uM, shows potent antibacterial activity against strain BHKS211 with MIC of 16 ug/mL.
PC-24195	Xeruborbactam disodium Beta-lactamase inhibitor	Xeruborbactam (QPX7728) disodium is an ultrabroad-spectrum beta-lactamase inhibitor, inhibits class A extended-spectrum beta-lactamases with IC50 of 1-3 nM, carbapenemases such as KPC (IC50, 2.9 nM), class C P99 (IC50, 22 nM).
PC-23867	BRD1401 OprH-LPS inhibitor	BRD1401 is a P. aeruginosa-specific inhibitor targeting outer membrane protein OprH-LPS interaction, increases membrane fluidity.
PC-23749	Benurestat Urease inhibitor	Benurestat is a reversible competitive inhibitor of gut bacterial urease, inhibits ammonia production by urease-encoding gut bacteria, inhibits urease activity in mouse fecal suspensions ex vivo with IC50 of 2.5 uM.

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