| Cat. No. |
Product Name |
Information |
| PC-27918 |
AP-7-168
β2AR NAM
|
AP-7-168 is a specific β-arrestin-biased negative allosteric modulator (NAM) of β2-adrenergic receptor (β2AR), mediates β2AR dimerization with pEC50 of 5.93 in HEK cells, is >1,000-fold effective at inhibiting β-arrestin2 recruitment versus cAMP production. |
| PC-25680 |
β1AR antagonist Compound 11
β1AR modulator
|
β1AR antagonist Compound 11 (β1AR PAM antagonist C11) is a selective, allosteric modulator of β1-adrenergic receptor (β1AR) and PAM antagonist, selectively potentiates the binding affinity of orthosteric agonists to the β1AR while potently inhibiting downstream signaling following β1AR activation. |
| PC-25232 |
ADRIANA
α2B adrenoceptor antagonist
|
ADRIANA (c545) is a potent, orally active α2B adrenoceptor subtype-specific antagonist with binding Ki of 987 nM, >50-fold selective over α2A adrenoceptor. |
| PC-24799 |
ATR-258
β2AR agonist
|
ATR-258 (Compound 15) is a specific GRK-biased β2 adrenergic receptor (β2AR) agonist with pEC50 of 6.87, increases glucose uptake with low cAMP generation. |
| PC-24568 |
CCF219B
α1A-AR PAM
|
CCF219B (Compound 3, Cmpd-3) is a potent, selective positive allosteric modulator of the α1A-adrenergic receptor (α1A-AR) with an affinity of 30 nM, 10-50-fold selectivity against the α1B- and α1D-AR subtypes. |
| PC-22600 |
WB4101
α1A adrenoceptor antagonist
|
WB4101 is a potent, α1A-adrenergic selective antagonist with pKB value of 8.9 in rabbit aorta. |
| PC-21196 |
Mirabegron
β3-adrenoceptor agonist
|
Mirabegron (YM178) is a potent, selective selective β3-adrenoceptor agonist with EC50 of 22.4 nM. |
| PC-20987 |
Difluorophenyl Quinazoline
β2AR NAM
|
Difluorophenyl Quinazoline (DFPQ, AP-06-202) is a selective, biased, negative allosteric modulator (NAM) of β-arrestin recruitment to β2-adrenergic receptor (β2AR), without effect on on β2AR coupling to Gs. |
| PC-20804 |
Nebivolol hydrochloride
Beta adrenergic antagonist
|
Nebivolol hydrochloride (R 065824) is a beta adrenergic antagonist and shows direct vasodilator properties and adrenergic blocking characteristics. |
| PC-20307 |
BAY-6096
Adrenergic α2B inhibitor
|
BAY-6096 (BAY6096) is a potent, selective, and highly water-soluble adrenergic α2B antagonist with IC50 of 14 nM. |
| PC-49058 |
AS408
β2AR NAM
|
AS408 (AS-408) is a negative allosteric modulator (NAM) of the β2-adrenergic receptor (β2AR) for both G-protein activation and arrestin recruitment (pKB=6.8, [35S]GTPγS binding assays). |
| PC-47093 |
Tasipimidine
α2A adrenoceptor agonist
|
Tasipimidine is a potent, selective and orally active human α2A-adrenoceptor agonist with pEC50 of 7.57, >100-fold selectivity over α2B-and α2C-adrenoceptors and the rodent α2D-adrenoceptor. |
