| Cat. No. |
Product Name |
Information |
| PC-27965 |
Jaktinib hydrochloride
JAK inhibitor
|
Jaktinib hydrochloride (Gecacitinib, Momelotinib-3,3,5,5-d4) is a deuterated form of momelotinib and selective JAK1/2 inhibitor with IC50 of 0.1 μM on cells transformed by selected oncogenic mutants of tyrosine kinases, inhibits activity of JAK1, JAK2, JAK3, and TYK2, blocks the JAK-STAT signaling pathway. |
| PC-27964 |
Gecacitinib
JAK inhibitor
|
Gecacitinib (Jaktinib, Momelotinib-3,3,5,5-d4) is a deuterated form of momelotinib and selective JAK1/2 inhibitor with IC50 of 0.1 μM on cells transformed by selected oncogenic mutants of tyrosine kinases, inhibits activity of JAK1, JAK2, JAK3, and TYK2, blocks the JAK-STAT signaling pathway. |
| PC-27425 |
Fadeucravacitinib
TYK2 inhibitor
|
Fadeucravacitinib (ICP-488) is a potent and selective, allosteric TYK2 inhibitor with IC50 of 5.7 nM for TYK2-JH2, blocks the signal transduction of IL-23, IL-12, type 1 IFN and other inflammatory cytokine, thereby inhibiting the pathological process of autoimmune and inflammatory diseases. |
| PC-27421 |
Embricitinib
JAK inhibitor
|
Embricitinib is a potent, selective JAK1 inhibitor with IC50 of 0.15 nM, 3.69 nM, 3.10 nM and 1.49 nM for JAK1, JAK2, JAK3 and TYK2 respectively. |
| PC-27420 |
Durocitinib
TYK2 inhibitor
|
Durocitinib is a potent, selective TYK2 inhibitor. |
| PC-27282 |
TYK2 activator 6g
TYK2 activator
|
TYK2 activator 6g is a potent, selective small molecule TYK2 activator with EC50 of 0.21 uM (JH1/JH2 TYK2), maximal activation effect (Emax) of 7.8-fold. |
| PC-27281 |
HHT-9041P1
JAK1 inhibitor
|
HHT-9041P1 is a potent and selective JAK1 inhibitor with IC50 of 612 nM, displays 10-, 23- and 63-fold selective over JAK2, JAK3 and TYK2. |
| PC-26418 |
YYSW001
JAK1 inhibitor
|
YYSW001 is a potent, highly selective and orally bioavailable JAK1 inhibitor with IC50 of 6 nM, with no activity against JAK2 and JAK3. |
| PC-26362 |
Vexicitinib
JAK/SYK inhibitor
|
Vexicitinib (SYHX1901) is a potent, selective dual JAK/SYK inhibitor, interrupts both the IL-23/IL-17 axis and B-cell-dependent amplification loops, shows anti-inflammatory and immunosuppressant activities. |
| PC-26345 |
Nomelcitinib
Tyk2 inhibitor
|
Nomelcitinib (D-2570) is a potent, selective tyrosine kinase 2 (TYK2) inhibitor, selectively binds to the JH2 domain of TYK2. |
| PC-26282 |
H018
JAK1/2 inhibitor
|
H018 (RAI-20) is a highly potent, selective JAK1/2 inhibitor with IC50 of 15.1/22.7 nM, >10-fold and 20-fold selective over JAK3 amd TYK2, displays robust anti-arthritic efficacy. |
| PC-26072 |
ARTS-011
Tyk2 inhibitor
|
ARTS-011 is a potent, selective, allosteric and oral inhibitor of Tyk2, selectively targeting the JH2 domain of the Tyk2 protein. |
