| Cat. No. |
Product Name |
Information |
| PC-27829 |
SIK3 inhibitor 39
SIK3 inhibitor
|
SIK3 inhibitor 39 is a potent, selective salt-inducible kinase 3 (SIK3) inhibitor with IC50 of 15 nM, shows 8-fold and 13-fold selectivity over SIK1 and SIK2 respectively. |
| PC-27828 |
SIK3-IN-1
SIK3 inhibitor
|
SIK3-IN-1 (Cmpd-219) is a potent, selective salt-inducible kinase 3 (SIK3) inhibitor with IC50 of 10 nM, shows >50-fold selectivity over SIK1 and SIK2. |
| PC-25910 |
PF-07899895
SIK inhibitor
|
PF-07899895 is a potent pan-SIK inhibitor with IC50 of 1.2 nM, 0.9 nM and 1.8 nM for SIK1, SIK2 and SIK3, respectively. |
| PC-25118 |
GLPG4970
SIK2/3 inhibitor
|
GLPG4970 is a highly potent, selective dual SIK2/SIK3 inhibitor with IC50 of 0.3/0.7 nM respectively. |
| PC-22043 |
SIC-19
SIK2 inhibitor, SIK2 degrader
|
SIC-19 is a potent, selective SIK2 inhibitor, promotes SIK2 protein degradation via the ubiquitination pathway, exhibits synthetic lethality with PARP inhibitors in ovarian cancer. |
| PC-21590 |
HG-9-91-01
SIK inhibitor
|
HG-9-91-01 is a potent, highly selective salt-inducible kinase (SIK) inhibitor with IC50 of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively. |
| PC-21587 |
GLPG3312
SIK inhibitor
|
GLPG3312 is a potent and selective pan-SIK inhibitor with IC50 of 2.0/0.7/0.6 nM for SIK1/SIK2/SIK3, respectively. |
| PC-21585 |
JRD-SIK1/2i-4
SIK1/2 inhibitor
|
JRD-SIK1/2i-4 is a potent, highly selective SIK1/2 inhibitor, modulates innate immune activation and suppress intestinal inflammation. |
| PC-20664 |
GLPG3970
SIK2/3 inhibitor
|
GLPG3970 (GLPG 3970) is a potent, selective first-in-class salt inducible kinase SIK2/SIK3 inhibitor with IC50 of 7.8/3.8 nM, respectively. |
| PC-49563 |
SK-124
SIK2/SIK3 inhibitor
|
SK-124 (SK124) is a potent, selective, orally active SIK2/SIK3 inhibitor with IC50 of 8.8/11.3 nM in cell-based NanoBRET assays, 15-fold selectivity versus SIK1. |
| PC-72723 |
MRIA9
dual SIK/PAK inhibitor
|
MRIA9 is a potent, selective dual SIK/PAK inhibitor, inhibits SIK1/2/3 with cellular IC50 of 586/180/127 nM, respectively. |
| PC-63124 |
rac Pterosin B
SIK3 inhibitor
|
rac Pterosin B is a potent and specific SIK3 signaling inhibitor that suppresses SIK3 downstream cascades by up-regulating the phosphorylation levels in the SIK3 C-terminal regulatory domain. |
