| Cat. No. |
Product Name |
Information |
| PC-27646 |
AM-8719
KRAS G12C inhibitor
|
AM-8719 (AM8719) is a potent, selective, CNS-penetrant, orally efficacious KRAS G12C inhibitor with cellular activity (p-ERK, IC50=157 nM). |
| PC-27628 |
KRAS-Q61X inhibitor compound 2
KRAS-Q61X inhibitor
|
KRAS-Q61X inhibitor compound 2 is a specific small molecule ligand of KRAS-Q61X (X = H, L, K, R), selectively activates GTP hydrolysis of KRAS-Q61X, suppresses KRAS-Q61X signaling. |
| PC-27627 |
KRAS-Q61X inhibitor compound 1
KRAS-Q61X inhibitor
|
KRAS-Q61X inhibitor compound 1 is a specific small molecule ligand of KRAS-Q61X (X = H, L, K, R), selectively activates GTP hydrolysis of KRAS-Q61X mutants. |
| PC-27075 |
RMC-8839
KRAS G13C inhibitor
|
RMC-8839 (RMC8839) is a potent, selective, covalent and orally active RAS(ON) G13C tri-complex inhibitor with biochemical Kinact of 2.83 x 10-3 s-1 and Ki of 28.3 nM. |
| PC-26762 |
RMC-5127
RAS(ON) G12V inhibitor
|
RMC-5127 (RMC5127) is a potent, selective and orally bioavailable RAS(ON) G12V inhibitor with EC50 of 2.1 nM, 26-fold selective over RAS WT. |
| PC-26456 |
DJX-A-KM
KRASG12C degrader
|
DJX-A-KM is a potent, selective FBXO28-recruiting degrader of KRASG12C with DC50 of 2 nM in NCI-H23 cells, Dmax=98%. |
| PC-26265 |
IACS-56676
NRAS G12D inhibitor
|
IACS-56676 is a selective and potent NRAS G12D inhibitor with target engagement IC50 of 31 nM in AlphaLISA p-ERK1/2 assays, and IC50 of 73 nM in THP1 cell viability assay, displays >100-fold selectivity for NRAS G12D over KRAS wild type. |
| PC-26023 |
Dual SLC25A51 and SDHA inhibitor 615
SLC25A51/SDHA inhibitor
|
Dual SLC25A51 and SDHA inhibitor 615 (Compound 615, 666-15) is a specific small molecule dual inhibitor of SLC25A51 and succinate dehydrogenase (SDH) subunit SDHA, selectively kills KRAS-mutated cells. |
| PC-25973 |
RNK08954
KRAS G12D inhibitor
|
RNK08954 is a potent, selective, non-covalent and orally bioavailable KRAS G12D inhibitor, binds primarily to the inactive KRAS G12D (GDP-bound) with SPR KD of 39.5 pM and to the active KRAS G12D (GTP-bound) form with KD of 12.2 nM. |
| PC-25958 |
Deltafluorine
PDEδ inhibitor
|
Deltafluorine is a specific small molecule PDEδ inhibitor with ITC KD of 148 nM and binding IC50 of 25 nM, targeting the binding site glutamate p.E88 in PDEδ, impairs K-Ras signaling. |
| PC-25265 |
MCB-294
KRAS inhibitor
|
MCB-294 is a potent, selective, dual-state pan-KRAS inhibitor capable of binding both the active (GTP-bound) and inactive (GDP-bound) forms of KRAS, effectively inactivates both wild-type KRAS and multiple KRAS mutants. |
| PC-24662 |
AMG410
KRAS inhibitor
|
AMG410 is a potent, non-covalent and selective pan-KRAS inhibitor with IC50 values of 1-4 nM for KRAS G12D, KRAS G12V, and KRAS G13D,> 100-fold selectivity against both HRAS and NRAS. |
