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Cat. No. Product Name CAS No. Information
PC-38438

MRTX-EX185

MRTX-EX185 (EX185) is a novel potent small-molecule inhibitor of KRAS mutants, exhibits target engagement against KRAS(G12D) with IC50 of 90 nM, binds to GDP-loaded KRAS and KRAS(G12D), as well as the active GNP state.
PC-73313

MRTX 0902

2654743-22-1 MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK).
PC-73005

TH-Z835

2766209-50-9 TH-Z835 is a potent, mutant selective KRAS (G12D) inhibitor with IC50 of 1.6 uM.
PC-72897

JDQ443

2653994-08-0 JDQ443 (NVP-JDQ443) is a potent, mutant-selective, covalent KRAS G12C inhibitor.
PC-38327

K-Ras G12D inhibitor KS-58

K-Ras G12D inhibitor KS-58 is the first K-Ras(G12D) selective, bicyclic peptide inhibitor with binding Ki of 22 nM.
PC-38296

BI-3406

2230836-55-0 BI-3406 (BI 3406) is a highly potent and selective SOS1-KRAS interaction inhibitor with IC50 of 5 nM, binds to the catalytic domain of SOS1 with Kd of 9.7 nM.
PC-36062

ZT-12-037-01

2328073-61-4 ZT-12-037-01 is a potent, selective, ATP-competitive STK19 inhibitor with IC50 of 20.04 nM measured as percentage of NRAS phosphorylation.

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