| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-38549 |
AZD4625
|
2387927-95-7 |
AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM. |
| PC-38438 |
MRTX-EX185
|
|
MRTX-EX185 (EX185) is a novel potent small-molecule inhibitor of KRAS mutants, exhibits target engagement against KRAS(G12D) with IC50 of 90 nM, binds to GDP-loaded KRAS and KRAS(G12D), as well as the active GNP state. |
| PC-73419 |
Garsorasib
|
2559761-14-5 |
Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines. |
| PC-73323 |
GDC-6036
|
2417987-45-0 |
GDC-6036 (Divarasib, RG6330) is a potent, selective, covalent and orally available KRAS G12C inhibitor with HTRF IC50 of 2.9 pM. |
| PC-73313 |
MRTX 0902
|
2654743-22-1 |
MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK). |
| PC-73005 |
TH-Z835
|
2766209-50-9 |
TH-Z835 is a potent, mutant selective KRAS (G12D) inhibitor with IC50 of 1.6 uM. |
| PC-72958 |
ASP2453
|
2241719-73-1 |
ASP2453 (ASP-2453) is a novel potent, selective and covalent KRAS G12C inhibitor, inhibits SOS-mediated interaction between KRAS G12C and Raf with IC50 of 40 nM. |
