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Cat. No. Product Name CAS No. Information
PC-38549

AZD4625

2387927-95-7 AZD4625 is a potent, selective, covalent allosteric inhibitor of mutant GTPase KRAS G12C with IC50 of 3 nM, inhibitor H358 cell proliferation with GI50 of 4 nM.
PC-38438

MRTX-EX185

MRTX-EX185 (EX185) is a novel potent small-molecule inhibitor of KRAS mutants, exhibits target engagement against KRAS(G12D) with IC50 of 90 nM, binds to GDP-loaded KRAS and KRAS(G12D), as well as the active GNP state.
PC-73419

Garsorasib

2559761-14-5 Garsorasib (D-1553) is a potent, selective, orally bioavailable and covalent KRas-G12C inhibitor with IC50 of 10 nM, exhibits potent anti-tumor activity in a broad spectrum of tumor cell lines.
PC-73323

GDC-6036

2417987-45-0 GDC-6036 (Divarasib, RG6330) is a potent, selective, covalent and orally available KRAS G12C inhibitor with HTRF IC50 of 2.9 pM.
PC-73313

MRTX 0902

2654743-22-1 MRTX0902 is a highly potent, selective SOS1 inhibitor with binding IC50 of 2 nM, cellular IC50 of 33 nM (pERK).
PC-73005

TH-Z835

2766209-50-9 TH-Z835 is a potent, mutant selective KRAS (G12D) inhibitor with IC50 of 1.6 uM.
PC-72958

ASP2453

2241719-73-1 ASP2453 (ASP-2453) is a novel potent, selective and covalent KRAS G12C inhibitor, inhibits SOS-mediated interaction between KRAS G12C and Raf with IC50 of 40 nM.

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