| Cat. No. |
Product Name |
Information |
| PC-20956 |
ADS032
|
ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM. |
| PC-38558 |
GSK669
|
GSK669 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling (IC50=0.5 uM), has an IC50 of 3.2 uM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells. |
| PC-38421 |
Selnoflast
|
Selnoflast (RO7486967) is an orally active, potent, selective and reversible small molecule NLRP3 inhibitor. |
| PC-73215 |
Emlenoflast
|
Emlenoflast (MCC7840, Inzomelid, IZD174) is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of <100 nM. |
| PC-35137 |
CY-09
|
CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity. |
| PC-35078 |
Oridonin
|
Oridonin is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK. |
| PC-43228 |
MCC950
|
MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3. |
