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Cat. No. Product Name Information
PC-20956

ADS032

ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM.
PC-38558

GSK669

GSK669 is a potent, selective NOD2 (nucleotide-binding oligomerization domain 2) inhibitor, inhibits muramyl dipeptide (MDP)-induced NOD2-mediated signaling (IC50=0.5 uM), has an IC50 of 3.2 uM for MDP-stimulated IL-8 secretion in HEK293/hNOD2 cells.
PC-38421

Selnoflast

Selnoflast (RO7486967) is an orally active, potent, selective and reversible small molecule NLRP3 inhibitor.
PC-73215

Emlenoflast

Emlenoflast (MCC7840, Inzomelid, IZD174) is a potent and selective inhibitor of NLRP3 inflammasome with IC50 of <100 nM.
PC-35137

CY-09

CY-09 (NLRP3 inhibitor CY-09) is a selective and direct NLRP3 inhibitor, binds to the ATP-binding motif of NLRP3 NACHT domain and inhibits NLRP3 ATPase activity.
PC-35078

Oridonin

Oridonin is a high-affinity NLRP3 inflammasome inhibitor (Kd=52.5 nM), covalently binds within NACHT domain, blocks interaction of NLRP3 with NEK.
PC-43228

MCC950

MCC950 (CP-456773) is a potent, selective, small-molecule inhibitor of NLRP3 inflammasome with IC50 of 7.5 and 8.1 nM in BMDM and HMDM, respectively, specifically inhibits activation of NLRP3, does not inhibit NLRC4, AIM2, TLR signalling or priming of NLRP3.

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