| Cat. No. |
Product Name |
Information |
| PC-23831 |
AZD4144
NLPR3 inhibitor
|
AZD4144 is a potent, direct and selective NLPR3 inflammasome inhibitor with IC50 of 76 nM (inhibition of nigericin-triggered speck formation), inhibits LPS/ATP-induced IL-1β and IL-18 release in mouse with IC50 of 54 nM. |
| PC-22057 |
BAL-0028
NLRP3 inhibitor
|
BAL-0028 (BAL0028) is a potent, selective and reversible inhibitor of NLRP3 activation with IC50 of 25 nM, binds to the NACHT domain of NLRP3 with Kd of 104-123 nM. |
| PC-21694 |
YQ128
NLRP3 inhibitor
|
YQ128 is potent, second-generation inhibitor of the NOD-like receptor protein 3 (NLRP3) inflammasome with IC50 of 0.3 uM. |
| PC-21639 |
NP3-146
NLRP3 inhibitor
|
NP3-146 is a small molecule NLRP3 inflammasome inhibitor and an analog of MCC950. |
| PC-21638 |
NP3-562
NLRP3 inhibitor
|
NP3-562 is a potent, orally bioavailable NLRP3 inflammasome inhibitor, inhibits IL-1β in nigericin-stimulated THP-1 cells with IC50 of 90 nM. |
| PC-21637 |
ZYIL1
NLRP3 inhibitor
|
ZYIL1 (Usnoflast) is a potent, orally active, selective NLRP3 inflammasome inhibitor, Nigericin-mediated interleukin (IL)-1β release in isolated microglia cells with IC50 of 43 nM. |
| PC-21283 |
NT-0796
NLRP3 inhibitor
|
NT-0796 is a potent, selective and brain-penetrant NLRP3 inflammasome inhibitor, inhibits IL-1β release from human PBMC cells with IC50 of 0.32 nM. |
| PC-21282 |
DFV890
NLRP3 inhibitor
|
DFV890 (NVP-DFV890, IFM-2427) is a potent, selective and orally active inhibitor of NLRP3 inflammasome, directly binds to NLRP3 and locks the protein in an inactive conformation, prevents NLRP3 inflammasome assembly in response to sterile danger signals. |
| PC-20956 |
ADS032
NLRP1/NLRP3 inhibitor
|
ADS032 (ADS-032) is the first, reversible and stable dual NLRP1 and NLRP3 inflammasome inhibitor, inhibits nigericin‐induced NLRP3‐induced IL‐1β secretion from LPS‐primed iBMDMs with IC50 of 30 uM. |
| PC-20303 |
JC124
NLRP3 inhibitor
|
JC124 is a potent selective NLRP3 inflammasome inhibitor with IC50 of 3.25 uM for inhibition of IL-1β release by LPS/ATP-stimulated J774A.1 cells. |
| PC-20225 |
JC2-11
Inflammasome inhibitor
|
JC2-11 is an anti-inflammasome compound and a pan-inhibitor of the NLRP3, NLRC4, and AIM2 inflammasomes. |
| PC-49812 |
ML146
NOD1 inhibitor
|
ML146 (ML-146, Pubmed CID-1088438) is a selective small molecule NOD1 inhibitor with IC50 of 1.5 uM in NOD1 agonist-stimulated NF-κB reporter assay in HEK293T cells. |
