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Cat. No. Product Name Information
PC-20482

K786-4469

TMEM16A inhibitor

K786-4469 is a small molecule inhibitor of anoctamin 1 (ANO1), suppresses cancer metastasis in vitro and in vivo.
PC-20364

Ani9

TMEM16A inhibitor

Ani9 is a potent, selective anoctamin1 (ANO1, TMEM16A) channel inhibitor with IC50 of 107 nM, with negligible effect on ANO2 (IC50>10 uM).
PC-20363

CaCCinh-A01

CaCC/TMEM16A inhibitor

CaCCinh-A01 is a small molecule Ca(2+)-activated Cl(-) channel (CaCC) inhibitor, inhibits both I(sc) and transepithelial conductance in a concentration-dependent manner (IC50=6.3 uM).
PC-49192

TMEM16A blocker 1PBC

TMEM16A blocker

1PBC is a small molecule blocker of calcium-activated chloride channel TMEM16A, blocks TMEM16A completely with an IC50 of 4 uM at zero mV and saturating Ca2+ concentration (2 uM).
PC-47048

TMinh-23

TMEM16A inhibitor

TMinh-23 is (Compound 10bm) is a potent, selective inhibitor of transmembrane protein 16A (TMEM16A or ANO1, DOG1, ORAOV2, TAOS-2) with IC50 of 30 nM in short-circuit current assays, weakly inhibits TMEM16B (IC50=400 nM, 13 -fold selectivity).
PC-38752

DRAinh-A270

SLC26A3 inhibitor

DRAinh-A270 is a small-molecule, selective inhibitor of intestinal anion exchanger SLC26A3 (DRA), inhibits SLC26A3-mediated chloride/bicarbonate exchange with IC50 of 35 nM and oxalate/chloride exchange with IC50 of 60 nM.
PC-38691

VI-116

VRAC inhibitor

VI-116 is a potent and selective volume-regulated anion channel (VRAC) inhibitor, fully inhibits VRAC-mediated I- quenching with an IC50 of 1.27 uM in LN215 cells.
PC-38479

MONNA

TMEM16A inhibitor

MONNA a potent, selective inhibitor of the TMEM16A calcium-activated chloride channel (Anoctamin-1, ANO1) with IC50 of 80 nM (xANO1).
PC-72552

CLC-2-IN-AK42

CLC-2 inhibitor

CLC-2-IN-AK42 (CLC-2 inhibitor AK42, AK42) is a potent, specific small-molecule inhibitor of voltage-gated chloride channel CLC-2 with IC50 of 17 nM (human CLC-2).
PC-38096

NS3728

VRAC inhibitor

NS3728 (Emidurdar, SCO-101) is a potent volume-regulated anion channel (VRAC) blocker with IC50 of 460 nM.
PC-35990

T16Ainh-A01

TMEM16A inhibitor

T16Ainh-A01 is an inhibitor of the calcium-activated chloride channel TMEM16A, inhibits Ca2+-activated Cl− channel (CACC) activity in TMEM16A-transfected FRT cells with IC50 of 1 uM.
PC-35775

CLP290

KCC2 activator

CLP290 (CLP-290) is an orally acirtve small molecule K+-Cl- cotransporter isotype 2 (KCC2) activator, the carbamate prodrug of CLP257.

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