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(R)-(-)-Rolipram

Chemical Structure : (R)-(-)-Rolipram

CAS No.: 85416-75-7

(R)-(-)-Rolipram ((R)-Rolipram;(-)-Rolipram)

Catalog No.: PC-45081Not For Human Use, Lab Use Only.

A more active enantiomer of the PDE4 inhibitor rolipram.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

A more active enantiomer of the PDE4 inhibitor rolipram; shows 2-10-fold more potent than the S-(+) enantiomer rolipram.

Asthma

Phase 2 Clinical

Physicochemical Properties

M.Wt 275.3428
Formula C16H21NO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 49 mg/mL

Chemical Name/SMILES

2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-, (4R)-

References

1. Schneider HH, et al. Eur J Pharmacol. 1986 Aug 7;127(1-2):105-15.

2. Owens RJ, et al. Biochem J. 1997 Aug 15;326 ( Pt 1):53-60.

3. Ohsawa F, et al. Jpn J Pharmacol. 1998 Jun;77(2):147-54.

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