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Chemical Structure : (R,S)-MNF
Catalog No.: PC-38003Not For Human Use, Lab Use Only.
(R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells).
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(R,S′)-MNF is a bi-functional GPR55 inhibitor and biased β2 adrenergic agonist, inhibits proliferation of PDAC cell lines (IC50=0.11 uM, PANC-1 cells).
(R,S′)-MNF is a biased β2-AR agonist that selectively signals through Gαs and does not recruit β-arrestin-2.
(R,S′)-MNF attenuates pro-oncogenic signaling and cellular proliferation in PANC-1 cells.
(R,S′)-MNF (1 uM) significantly decreased ERK phosphorylation stimulated by the GPR55 ligand O-1602, (R,S′)-MNF is an effective inhibitor of GPR55 internalization and signaling.
(R,S′)-MNF (20-40 mg/Kg) reduces PANC-1 tumor growth in a mouse xenograft model.
| M.Wt | 367.445 | |
| Formula | C22H25NO4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Artur Wnorowski, et al. Sci Rep. 2022 Mar 7;12(1):3618.
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