(RS)-G12Di-1

Chemical Structure : (RS)-G12Di-1

Catalog No.: PC-24256Not For Human Use, Lab Use Only.

(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D.

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Biological Activity

(RS)-G12Di-1 is a selective, covalent inhibitor of K-Ras-G12D.
(RS)-G12Di-1 showed markedly reduced reactivity with K-Ras-G12E•GDP.
(RS)-G12Di-1 also active against the GppNHp-bound K-Ras-G12D.
The covalent modification of Asp12 by (RS)-G12Di-1 stabilized both K-Ras-G12D•GDP and K-Ras-G12D•GppNHp toward thermal denaturation (ΔTm = +10.3 °C and +2.5 °C, respectively).

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

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(RS)-G12Di-1

Biological Activity

Physicochemical Properties

References

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