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Chemical Structure : (S)-3,4-DCPG
Catalog No.: PC-22229Not For Human Use, Lab Use Only.
(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM).
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(S)-3,4-DCPG ((S)-3,4-Dicarboxyphenylglycine) is a potent and selective mGlu8 receptor (mGluR8) agonist with EC50 of 31 nM in cell-based assays, with no acitivity against other mGlu receptors (IC50>3,500 nM).
(S)-3,4-DCPG depressed the fast component of the dorsal root-evoked ventral root potential (fDR-VRP) giving a biphasic concentration-response curve showing EC50 of 1.3 uM.
(S)-3,4-DCPG activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord.
(S)-3,4-DCPG (100 mg/kg) significantly increased c-Fos expression in several stress-related brain regions: paraventricular nucleus of the hypothalamus, central nucleus of the amygdala, lateral parabrachial nucleus and locus coeruleus in mice.
| M.Wt | 239.18 | |
| Formula | C10H9NO6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Thomas NK, et al. Neuropharmacology. 2001 Mar;40(3):311-8.
2. Linden AM,et al. Neuropharmacology. 2003 Sep;45(4):473-83.
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