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Chemical Structure : (S)-PBMC
Catalog No.: PC-60788Not For Human Use, Lab Use Only.
A novel potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8).
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A novel potent, selective TRPM8 antagonist with IC50 of 15.6 nM (hTRPM8); antagonizes in vitro activation of human and guinea-pig TRPM8 and reverses menthol and cold-induced facilitation of the micturition reflex at plasma concentrations consistent with in vitro potencies.
| M.Wt | 434.536 | |
| Formula | C26H30N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Gardiner JC, et al. Eur J Pharmacol. 2014 Oct 5;740:398-409.
2. Knowlton WM, et al. PLoS One. 2011;6(9):e25894.
3. Sałat K, et al. Curr Med Chem. 2013;20(11):1409-36.
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