1-AM (1_AM) | KRAS G12C inhibitor | Probechem Biochemicals

Chemical Structure : 1-AM

1-AM (KRAS G12C inhibitor 1_AM, 1_AM)

Catalog No.: PC-61202Not For Human Use, Lab Use Only.

1-AM (1_AM) is a potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.

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Biological Activity

1-AM (1_AM) is a potent, selective, covalent KRAS G12C inhibitor that selectively inhibit KRAS G12C-dependent signaling and cancer cell growth at sub-micromolar concentrations.

Physicochemical Properties

M.Wt	510.998
Formula	C26H28ClFN6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-((4-(4-acryloylpiperazin-1-yl)-6-chloro-7-(2-fluorophenyl)quinazolin-2-yl)amino)-N,N-dimethylpropanamide

References

1. Zeng M, et al. Cell Chem Biol. 2017 Aug 17;24(8):1005-1016.e3.

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1-AM (KRAS G12C inhibitor 1_AM, 1_AM)

Biological Activity

Physicochemical Properties

References

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