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Chemical Structure : 103D5R
Catalog No.: PC-62894Not For Human Use, Lab Use Only.
103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity.
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103D5R is a small-molecule inhibitor of HIF-1α that displays an EC50 of 35 uM against hypoxia-induced alkaline phosphatase enzymatic reporter activity; shows cell proliferation under normoxia in LN229 cell with IC50 of 26 uM, markedly decreases HIF-1α protein synthesis induced by hypoxia or cobaltous ions in a dose- and time-dependent manner; inhibits phosphorylation of Akt, SAPK/JNK and Erk1/2, prevents the activation of HIF-1 target genes under hypoxia such as VEGF and Glut-1.
| M.Wt | 335.407 | |
| Formula | C20H21N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Tan C, et al. Cancer Res. 2005 Jan 15;65(2):605-12.
2. Belozerov VE, et al. Anticancer Drugs. 2005 Oct;16(9):901-9.
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