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Chemical Structure : 13PCSK9i
Catalog No.: PC-72857Not For Human Use, Lab Use Only.
13PCSK9i is a highly potent PCSK9-LDLR disruptor peptide with EC50 of 2 nM, SPR Kd of 6.1 nM and 21 nM for hPCSK9 and mPCSK9.
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13PCSK9i is a highly potent PCSK9-LDLR disruptor peptide with EC50 of 2 nM, SPR Kd of 6.1 nM and 21 nM for hPCSK9 and mPCSK9.
13PCSK9i reduces plasma cholesterol levels and increases hepatic LDLR density in a dose-dependent manner.
13PCSK9i functions by a unique, allosteric mechanism and is the smallest molecule identified to date with in vivo PCSK9-LDLR disruptor function.
| M.Wt | 1647.955 | |
| Formula | C85H110N14O18S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Margaret E Brousseau, et al. Cell Chem Biol. 2022 Feb 17;29(2):249-258.e5.
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