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Chemical Structure : 17-AAG
CAS No.: 75747-14-7
Catalog No.: PC-42457Not For Human Use, Lab Use Only.
17-AAG (Tanespimycin) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $58 | In stock | |
| 25 mg | $98 | In stock | |
| 50 mg | $148 | In stock | |
| 100 mg | $218 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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17-AAG (Tanespimycin) is a potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays.
17-AAG induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells.
17-AAG causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor.
17-AAG inhibits prostate cancer xenografts growth in mice.
| M.Wt | 585.6884 | |
| Formula | C31H43N3O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 55 mg/mL |
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| Chemical Name/SMILES |
Geldanamycin, 17-demethoxy-17-(2-propenylamino)- |
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1. Kamal A, et al. Nature. 2003 Sep 25;425(6956):407-10.
2. Solit DB, et al. Clin Cancer Res. 2002 May;8(5):986-93.
3. Nimmanapalli R, et al.Cancer Res. 2001 Mar 1;61(5):1799-804.
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