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Chemical Structure : 17-AAG hydrochloride
CAS No.: 911710-03-7
Catalog No.: PC-42458Not For Human Use, Lab Use Only.
A potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $80 | In stock | |
| 100 mg | $200 | In stock | |
| 200 mg | $280 | In stock |
Bulk size, bulk discount!
E-mail: sales@probechem.com
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A potent Hsp90 inhibitor with IC50 of 5 nM in cell-free assays; induces cytosolic accumulation of cytochrome c and cleavage and activities of caspase-9 and caspase-3, triggering apoptosis of HL-60/Bcr-Abl and K562 cells; causes the degradation of HER2, HER3, Akt, and both mutant and wild-type androgen receptor; inhibits prostate cancer xenografts growth in mice.
Skin Cancer
Phase 2 Discontinued
| M.Wt | 622.1494 | |
| Formula | C31H44ClN3O8 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Geldanamycin, 17-demethoxy-17-(2-propenylamino)-, monohydrochloride (9CI) |
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1. Kamal A, et al. Nature. 2003 Sep 25;425(6956):407-10.
2. Solit DB, et al. Clin Cancer Res. 2002 May;8(5):986-93.
3. Nimmanapalli R, et al.Cancer Res. 2001 Mar 1;61(5):1799-804.
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