Chemical Structure : 2-Cl-IB-MECA
CAS No.: 163042-96-4
Catalog No.: PC-43007Not For Human Use, Lab Use Only.
2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors.
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2-Cl-IB-MECA (Chloro-IB-MECA, CF-102, Namodenoson) is a potent, selective A3 adenosine receptor agonist with Ki of 0.33 nM, 2500- and 1400-fold selectivity over A1 and A2a receptors; also displays 46,000-fold selectivity versus the Na(+)-independent adenosine transporter; inhibits adenylate cyclase via rat A3 receptors in CHO cells (IC50=67 nM); induces apoptosis in HL-60 cells at concentrations of <30 uM, significantly induced Ca(2+) release from intracellular Ca(2+) pools followed by Ca(2+) influx; increases plasma histamine concentrations in conscious rats.
Liver Cancer
M.Wt | 544.7308 | |
Formula | C18H18ClIN6O4 | |
Appearance | Solid | |
Storage |
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Solubility |
DMSO: ≥ 31 mg/mL |
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Chemical Name/SMILES |
β-D-Ribofuranuronamide, 1-[2-chloro-6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-1-deoxy-N-methyl- |
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2. Kim HO, et al. J Med Chem. 1994 Oct 14;37(21):3614-21.
3. Kohno Y, et al. Biochem Biophys Res Commun. 1996 Feb 27;219(3):904-10.
4. Dunwiddie TV, et al. J Neurosci. 1997 Jan 15;17(2):607-14.
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