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2-Iminobiotin hydrobromide

Chemical Structure : 2-Iminobiotin hydrobromide

CAS No.: 76985-52-9

2-Iminobiotin hydrobromide (2-IB, Guanidinobiotin)

Catalog No.: PC-28057Not For Human Use, Lab Use Only.

2-Iminobiotin hydrobromide (2-IB, Guanidinobiotin) is a biotin analog with neuroprotective properties, is a selective, reversible inhibitor of neuronal and inducible nitric oxide synthase (NOS) with Ki of 21.8 and 37.5 uM for murine iNOS and rat n-cNOS.

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Biological Activity

2-Iminobiotin hydrobromide (2-IB, Guanidinobiotin) is a biotin analog with neuroprotective properties, is a selective, reversible inhibitor of neuronal and inducible nitric oxide synthase (NOS) with Ki of 21.8 and 37.5 uM for murine iNOS and rat n-cNOS.

Physicochemical Properties

M.Wt 324.24
Formula C10H18BrN3O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-((3aR,6S,6aS)-2-Amino-3a,4,6,6a-tetrahydro-1H-thieno[3,4-d]imidazol-6-yl)pentanoic acid hydrobromide

References

1. Sup SJ, et al. Biochem Biophys Res Commun. 1994 Oct 28;204(2):962-8.

2. Utkan T, et al. Pharmacol Biochem Behav. 2012 Jun;101(4):515-9.

3. Peeters-Scholte C, et al. PLoS One. 2023 Sep 25;18(9):e0291915.

4. Peeters-Scholte C, et al. Stroke. 2002 Sep;33(9):2304-10.

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