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Chemical Structure : 2-Methoxyestradiol
CAS No.: 362-07-2
Catalog No.: PC-42847Not For Human Use, Lab Use Only.
2-Methoxyestradiol (2ME2.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $48 | In stock | |
| 50 mg | $98 | In stock | |
| 100 mg | $178 | In stock | |
| 500 mg | Get quote |
Bulk size, bulk discount!
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2-Methoxyestradiol (2ME2;NSC-659853) is a metabolite of estradiol-17β and a novel antimitotic, antiangiogenic agent, binds to tubulin at or near the colchicine site and inhibits the polymerization of tubulin in vitro; suppresses microtubule dynamic instability in living interphase cells with mitotic IC50 of 1.2 uM, inhibits bFGF and VEGF-induced neovascularization and suppresses the growth of human breast carcinoma in mice; also downregulates hypoxia-inducible factor-1 (HIF) at the posttranscriptional level and inhibits HIF-1-induced transcriptional activation of VEGF expression.
| M.Wt | 302.4079 | |
| Formula | C19H26O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL |
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| Chemical Name/SMILES |
Estra-1,3,5(10)-triene-3,17-diol, 2-methoxy-, (17.beta.)- |
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3. Klauber N, et al. Cancer Res. 1997 Jan 1;57(1):81-6.
4. Mabjeesh NJ, et al. Cancer Cell. 2003 Apr;3(4):363-75.
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