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3-Bromopyruvic acid

Chemical Structure : 3-Bromopyruvic acid

CAS No.: 1113-59-3

3-Bromopyruvic acid (Bromopyruvic acid;3-Bromopyruvate)

Catalog No.: PC-45777Not For Human Use, Lab Use Only.

A glycolytic inhibitor that inhibits hexokinase II activity, suppresses ATP production, and induces endoplasmic reticulum (ER) stress.

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Biological Activity

A glycolytic inhibitor that inhibits hexokinase II activity, suppresses ATP production, and induces endoplasmic reticulum (ER) stress; potentiates acetate-induced apoptosis and anti-proliferative effect in CRC cells; abrogates MUC1-mediated radiation resistance both in vitro and in vivo pancreatic cancer models, by reducing glucose flux into nucleotide biosynthetic pathways and enhancing DNA damage.

Physicochemical Properties

M.Wt 166.9581
Formula C3H3BrO3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

H2O: ≥ 32 mg/mL

Chemical Name/SMILES

Propanoic acid, 3-bromo-2-oxo-

References

1. Can Z, et al. Anticancer Drugs. 2017 Aug;28(7):739-749.

2. Ferro S, et al. Oncotarget. 2016 Sep 21. doi: 10.18632/oncotarget.12156.

3. Gunda V, et al. Clin Cancer Res. 2017 Jul 18. pii: clincanres.1151.2017.

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