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Chemical Structure : 3-Deazauridine
CAS No.: 23205-42-7
Catalog No.: PC-38579Not For Human Use, Lab Use Only.
3-Deazauridine (DAU, NSC 126849) is a nucleoside analog that competitively inhibits cytidine triphosphate synthetase (CTP).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $108 | In stock | |
| 50 mg | $188 | In stock | |
| 100 mg | $328 | In stock | |
| 200 mg | $528 | In stock | |
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3-Deazauridine (DAU, NSC 126849) is a nucleoside analog that competitively inhibits cytidine triphosphate synthetase (CTP).
3-Deazauridine inhibits the growth of L1210 leukemia cells when used at a concentration of 6 µM and dose-dependently reduces mortality in a mouse model of leukemia.
3-Deazauridine selectively suppresses cell viability in a MYC-dependent manner in ARPE-19 cells.
3-Deazauridine causes selective replication stress in MYC-overexpressing cells, which originates from MYC-driven rRNA synthesis.
3-Deazauridine combined with ATR inhibitor BAY-1895344 induces synthetic lethality to MYC-overexpressing cells, and suppresses tumor growth in 3D assays and in vivo.
| M.Wt | 243.21 | |
| Formula | C10H13NO6 | |
| Appearance | Solid | |
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| Solubility |
10 mM in DMSO |
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1. Bloch, A., et al. J. Med. Chem. 16(3), 294-297 (1973).
2. Zhe Sun, et al. Cancer Res. 2022 Mar 15;82(6):1013-1024.
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