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Chemical Structure : 3-Methyladenine
CAS No.: 5142-23-4
Catalog No.: PC-45597Not For Human Use, Lab Use Only.
3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 uM and 60 uM in HeLa cells.
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|---|---|---|---|
| 100 mg | $88 | In stock | |
| 200 mg | $128 | In stock | |
| 500 mg | Get quote | ||
| 1 g | Get quote |
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3-Methyladenine (3-MA) is a selective PI3K inhibitor for Vps34 and PI3Kγ with IC50 of 25 uM and 60 uM in HeLa cells.
3-Methyladenine (3-MA) blocks class I PI3K persistently, whereas its suppressive effect on class III PI3K is transient.
3-Methyladenine (3-MA) induces caspase-dependent cell death in HeLa cells, and the death occurs independently of the inhibition of autophagy.
3-Methyladenine (3-MA) also blocks autophagosome formation.
| M.Wt | 149.1533 | |
| Formula | C6H7N5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 1.5 mg/mL; DMSO: 6.8 mg/mL (Need ultrasonic); H2O: 8.82 mg/mL (Need ultrasonic) |
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| Chemical Name/SMILES |
3H-Purin-6-amine, 3-methyl- |
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1. Miller S, et al. Autophagy. 2010 Aug;6(6):805-7.
2. Hou H, et al. PLoS One. 2012, 7(4), e35665.
3. Wu YT, et al. J Biol Chem. 2010, 285(14), 10850-10861.
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