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Chemical Structure : 4-Br-BnIm
Catalog No.: PC-61032Not For Human Use, Lab Use Only.
4-Br-BnIm is a potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α.
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4-Br-BnIm is a potent, subtype-selective Grp94 inhibitor with Kd of 0.96 uM, 13-fold selectivity over Hsp90α.
4-Br-BnIm facilitates mutant myocilin degradation and rescues phenotypes in a transgenic mouse model of hereditary primary open-angle glaucoma.
| M.Wt | 465.728 | |
| Formula | C20H18BrClN2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Stothert AR, et al. Sci Rep. 2017 Dec 20;7(1):17951.
2. Crowley VM, et al. J Med Chem. 2016 Apr 14;59(7):3471-88.
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