4-P-PDOT | Melatonin receptor MT2 antagonist

Chemical Structure : 4-P-PDOT

CAS No.: 134865-74-0

4-P-PDOT (4-phenyl-2-propionamidotetralin)

Catalog No.: PC-26838Not For Human Use, Lab Use Only.

4-P-PDOT is a potent, selective and high affinity melatonin receptor MT2 antagonist with pEC50 of 8.72 inhibition of forskolin stimulated cyclic AMP, >300-fold more selective for MT2 than MT1.

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Biological Activity

4-P-PDOT is a potent, selective and high affinity melatonin receptor MT2 antagonist with pEC50 of 8.72 inhibition of forskolin stimulated cyclic AMP, >300-fold more selective for MT2 than MT1.

Physicochemical Properties

M.Wt	279.38
Formula	C19H21NO
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide

References

1. Browning C, et al. Br J Pharmacol. 2000 Mar;129(5):877-86.

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4-P-PDOT (4-phenyl-2-propionamidotetralin)

Biological Activity

Physicochemical Properties

References

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