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Chemical Structure : 6-Hydroxy-DOPA
CAS No.: 21373-30-8
Catalog No.: PC-61924Not For Human Use, Lab Use Only.
6-Hydroxy-DOPA (6-OH-DOPA) is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $328 | In stock | |
| 50 mg | $528 | In stock | |
| 100 mg | Get quote |
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6-Hydroxy-DOPA (6-OH-DOPA) is a small-molecule that disrupts with RAD52 oligomerization, inhibits ssDNA binding by RAD52 with IC50 of 1.1 uM and by RAD52 (1 209) with IC50 of 1.6 uM.
6-Hydroxy-DOPA inhibits RAD52 foci formation in murine hematopoietic cells deficient in BRCA1, and kills BRCA-deficient cancer cells.
6-Hydroxy-DOPA also inhibits human apurinic/apyrimidinic endonuclease APE1 and enhances the cytotoxic and genotoxic potency of the alkylating agent methylmethane sulfonate.
| M.Wt | 213.189 | |
| Formula | C9H11NO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Alanine, 3-(2,4,5-trihydroxyphenyl)- (7CI,8CI) |
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1. Chandramouly G, et al. Chem Biol. 2015 Nov 19;22(11):1491-1504.
2. Simeonov A, et al. PLoS One. 2009 Jun 1;4(6):e5740.
3. Hengel SR, et al. Cell Chem Biol. 2017 Sep 21;24(9):1101-1119.
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