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740Y-P

Chemical Structure : 740Y-P

CAS No.: 1236188-16-1

740Y-P (740 Y-P, PDGFR 740Y-P)

Catalog No.: PC-25861Not For Human Use, Lab Use Only.

740Y-P (PDGFR 740Y-P, 740 Y-P) is a potent and cell-permeable PI3K activator/agonist, binds to SH2 domain of p85 regulatory subunit of PI3-kinase, induces iNOS expression and SGHPL-4 cell motility.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

740Y-P (PDGFR 740Y-P, 740 Y-P) is a potent and cell-permeable PI3K activator/agonist, binds to SH2 domain of p85 regulatory subunit of PI3-kinase, induces iNOS expression and SGHPL-4 cell motility.

Physicochemical Properties

M.Wt 3270.70
Formula C141H222N43O39PS3
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

L-Serine, L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparaginyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartylglycylglycyl-O-phosphono-L-tyrosyl-L-methionyl-L-α-aspartyl-L-methionyl-

References

1. D Derossi, et al. Biochem Biophys Res Commun. 1998 Oct 9;251(1):148-52.

2. Cartwright JE, et al. Exp Cell Res. 2002 Oct 1;279(2):219-26.

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