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Chemical Structure : A-1048400
Catalog No.: PC-60006Not For Human Use, Lab Use Only.
A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
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A-1048400 is a potent, selective, orally active N-type and T-type calcium channel blocker with IC50 of 1.4 and 1.2 uM, respectively.
A-1048400 shows no significant activity against L-type Ca2+ channels (IC50=28 uM).
A-1048400 reverses tactile allodynia in model of capsaicin-induced secondary hypersensitivity (EC50=300-365 ng/ml), without effect on hemodynamic function.
A-1048400 blocks native N- and T-type Ca2+ currents in rat dorsal root ganglion neurons (IC50=3.0 and 1.6 uM), attenuates nociceptive, neuropathic and inflammatory pain in vivo.
| M.Wt | 543.711 | |
| Formula | C36H37N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Scott VE, et al. Biochem Pharmacol. 2012 Feb 1;83(3):406-18.
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