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Chemical Structure : A-1592668
Catalog No.: PC-38149Not For Human Use, Lab Use Only.
A-1592668 (A 1592668) is a novel potent, CDK9-selective inhibitor with IC50 of 1.2 nM, >1000 fold selectivity over CDK1/2/7/8.
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A-1592668 (A 1592668) is a novel potent, CDK9-selective inhibitor with IC50 of 1.2 nM, >1000 fold selectivity over CDK1/2/7/8.
A-1592668 also displays selectivity of ~12- and 240-fold over CDK4 and CDK6 respectively.
A-1467729 inhibited phosphorylation of RNA pol-II (p-RNA pol-II; Ser2) with a potency of 26.7 nM at the cellular level, inhibited MCL-1 dependent hematologic tumor cell lines H929 (IC50=39 nM) and MV4-11 (IC50=42.4 nM) following 24 h of incubation.
| M.Wt | 467.517 | |
| Formula | C26H27F2N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Darren C Phillips, et al. Leukemia. 2020 Jun;34(6):1646-1657.
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