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Chemical Structure : A-286982
CAS No.: 280749-17-9
Catalog No.: PC-38443Not For Human Use, Lab Use Only.
A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50 of 44 and 35 nM in LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $108 | In stock | |
| 25 mg | $178 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote | ||
| 1 g | Get quote |
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A-286982 is a potent, nonpeptide inhibitor of LFA-1/ICAM-1 interaction with IC50 of 44 and 35 nM in LFA-1/ICAM-1 binding assay and LFA-1-mediated cellular adhesion assay, respectively.
The interaction between leukocyte function-associated antigen-1 (LFA-1), a member of the beta(2)-integrin family of adhesion molecules, and intracellular adhesion molecule ICAM-1 (CD54) is thought to play a critical role in the inflammatory process.
| M.Wt | 453.557 | |
| Formula | C24H27N3O4S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one |
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1. Liu G, et al. J Med Chem. 2000 Oct 19;43(21):4025-40.
2. Keating SM, et al. Protein Sci. 2006 Feb;15(2):290-303.
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